… As our results demonstrate that Stat3 is required for HIF-1α and VEGF upregulation
mediated by both Jak/STAT and PI3K/Akt pathways, Stat3 knockdown tumor cells might have …

… Supershift experiments with Stat3-specific antibodies demonstrate that Stat3 protein is
the predominant STAT family member activated in every case (Figure 1b). Because …

… -PCR analysis of VEGF-induced VEGF expression showed a … mediated reduction of STAT3
expression. Furthermore, studies … ) VEGF promotes the activation of the STAT pathway via the …

… of Stat signaling and associated with a decrease in VEGF, iNOS, eNOS, and bFGF
expression. The decrease in survival could be associated with the decrease in survivin level. …

… When STAT activation is uncontrolled, for example, through constitutive ligand/receptor … ,
aberrant STAT signaling may occur, even malignantly transform. Constitutive activation of STAT …

… signaling pathway is related to VEGF and bFGF expression, as … VEGF and bFGF mRNA
and protein expression by using AG490 and STAT3 siRNA to inhibit the JAK2/STAT3 signaling …

… that IL-17 induced JAK/STAT signaling pathway in a time-… the JAK/STAT signaling pathway,
and the IL-17/STAT pathway … the expression of VEGF by activating the JAK/STAT signaling …

… ), we hypothesized that VEGF signaling also involves the STAT signaling pathway. To
test this hypothesis, we treated cultured BAECs with recombinant human VEGF165 (rhVEGF165). …

… In addition, recent studies indicate that constitutive Stat3 signaling induces VEGF expression
and tumor angiogenesis, 6 suggesting that suppression of angiogenesis may further …

… The Janus-activated kinase (Jak)–STAT signaling plays a role in the … VEGF expression in
HASMCs. As shown in Figure 9AC, 14,15-EET had no significant effect on induction of VEGF in …