… normal T and B cells and in CLL. We aim to review these aspects of ZAP-70 involvement in
B cell malignancies, including methods of measuring ZAP-70 expression and an assessment …

… that the role of ZAP-70 in B cell malignancies is different from that in T cells. Interestingly,
despite the dispensable nature of its kinase activity, ectopic expression of ZAP-70 in the Burkitt …

… B-cell malignancies and suggest that the absence of ZAP-70 rather than its presence should
be considered abnormal for malignant B … by FC a wider spectrum of B-cell malignancies. …

… , ZAP-70 was negative in neoplastic cells in all cases tested. ZAP-70 staining in B-cell
lymphomas and reactive T cells was … By contrast, ZAP-70 staining in T/NK-cell lymphomas was …

… We measured ZAP-70 in both fresh and frozen cells in 25 patients, and results were … In 20
patients, we measured ZAP-70 in sequential samples. At least 10 8 freshly separated CLL cells …

… ZAP-70 expression and reveals that other B-cell malignant … active in other ZAP-70+ B-cell
malignant neoplasms remains … subset of MCL cases also express ZAP-70, because a subset of …

… of ZAP-70-positive cells detected by FC and the intensity of ZAP-70 by IHC is represented
in Figure 3. The number of positive cells detected by FC correlated well with the ZAP-70 …

… a relatively high level of ZAP-70, and patients with ZAP-70 High tumors tend to have shorter
overall survival. We also found that relatively high ZAP-70 expression in MCL significantly …

… T-cell lymphomas and CLLs but also in other B-cell lymphomas. As expected, ZAP-70 was
detected in the majority of T-cell malignant … ZAP-70, in the presence of residual normal T cells …

… the role of ZAP-70 in the biology of B-cell malignancies is still not … associated with ZAP-70
expression in primary CLL cells. … the role of ZAP-70 in the crosstalk between CLL cells and the …