… data on ZAP-70 mRNA expression and contemporaneous ZAP-70 protein expression for this
… We have profiled gene expression in purified lymphocytes from 107 patients with CLL and …

… In the present study, we have expanded this analysis by profiling gene expression in … gene
expression profiling studies of CLL. ZAP-70 was by far the best subgroup distinction gene in …

… ZAP-70 expression (Figure 3A). We reasoned that ZAP-70–dependent changes in gene
expression could easily be masked by the enormous genetic heterogeneity of CLL samples 15 (…

… CLL, depending on ZAP-70 expression, suggesting that the gene expression response to IL-…
links the gene expression response to IL-4, NFκB activity, and ZAP-70 expression, based on …

… this study were classified as ZAP-70 absent/low or ZAP-70 intermediate/high , although for
simplification we will refer to these samples as being ZAP-70 low versus ZAP-70 high (Table 1…

… between the expression of ZAP-70 in CLL cells and UM IgV H genes in agreement with the
… for the relation between ZAP-70 expression and IgV H mutational status are still unknown. …

… Gene expression profiling has shown that the genetic … ZAP-70 expression is a recognized
prognostic marker in chronic … of the ZAP-70 gene is associated with expression of the ZAP-70 …

… use nonmutated immunoglobulin V genes express ZAP-70 RNA.5 The functional significance
of ZAP-70 gene expression in this subgroup of CLL B cells is unknown. ZAP-70 is a PTK …

… signalling in normal B lymphocytes and that ZAP70 might directly enhance IgM signalling,
we wondered whether ZAP70 affects NF-κB target gene expression following IgM stimulation. …

… that expression analysis of a single gene, that is, the protein tyrosine kinase ZAP-70, could
… Thus, ZAP-70 gene expression may be used as a convenient surrogate marker of IgV H …