… , noninfected CLL cells or CLL cells infected with a control adenovirus vector. We conclude
that expression of ZAP-70 in CLL allows for more effective IgM signaling in CLL B cells, a …

… that expressed ZAP-70 induced significantly greater tyrosine phosphorylation of cytosolic …
stimulation of CLL cells that did not express ZAP-70. Also, exceptional cases of CLL cells that …

… the protein tyrosine kinase ZAP-70 may serve as a prognostic marker in B-CLL. Employing a
… examined purified leukemia B cells of 39 CLL patients for the expression of ZAP-70 mRNA …

… that we performed in ZAP-70 - CLL cells employed a T-cell-derived ZAP-70 construct, 17
suggesting that sequence or splicing variation of the ZAP-70 gene in CLL cells or T cells is not …

… that use unmutated Ig can generally be distinguished from CLL cells that use Ig with … the
70-kD zeta-associated protein (ZAP-70). ZAP-70 apparently enhances the capacity of CLL cells …

… for ZAP-70 positivity. The percentage of CLL cells with a high level of ZAP-70 expression is
… of each plot, after the exclusion of T and natural killer cells. FITC denotes Alexa Fluor 488. …

… ZAP-70+ CLL cells. We demonstrate that gefitinib preferentially induces cell death in ZAP-70-expressing
CLL cells with … of ZAP-70+ Jurkat T leukemia cells but fails to affect T cells from …

… activation of ZAP-70 in B cells and T cells by analyzing … of ZAP-70 is very inefficient in CLL
and lymphoma B cells and is … Despite the inefficient catalytic activation, the ability of ZAP-70 to …

… ZAP-70 could be used as a prognostic marker in CLL. … in these cells compared with CLL
cells. Our findings show a … of ZAP-70 mRNA and protein, and between ZAP-70 protein …

… The activated ZAP-70 can cooperate with Syk, the … B cells, thus inducing proliferation of
the CLL cells (10). The mechanisms of the abnormal expression of ZAP-70 in CLL cells, a B-cell …