Antibiotic-modulated microbiome suppresses lethal inflammation and prolongs lifespan in Treg-deficient mice
Abstract Background Regulatory T cell (Treg) deficiency leads to IPEX syndrome, a lethal
autoimmune disease, in Human and mice. Dysbiosis of the gut microbiota in Treg-deficient …
autoimmune disease, in Human and mice. Dysbiosis of the gut microbiota in Treg-deficient …
[HTML][HTML] Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation
N Tchitchek, ON Tchoumba, G Pires, S Dandou… - JCI insight, 2022 - ncbi.nlm.nih.gov
Gut microbiota dysbiosis is associated with inflammatory bowel diseases and with
cardiometabolic, neurological, and autoimmune diseases. Gut microbiota composition has a …
cardiometabolic, neurological, and autoimmune diseases. Gut microbiota composition has a …
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency
Treg deficiency causes a lethal, CD4+ T cell-driven autoimmune disease called IPEX
syndrome (immunodysregulation, polyendocrinopathy, and enteropathy, with X-linked …
syndrome (immunodysregulation, polyendocrinopathy, and enteropathy, with X-linked …
Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors
Regulatory T (T reg) cell deficiency causes lethal, CD4+ T cell–driven autoimmune
diseases. Stem cell transplantation is used to treat these diseases, but this procedure is …
diseases. Stem cell transplantation is used to treat these diseases, but this procedure is …
Microbiota-independent ameliorative effects of antibiotics on spontaneous Th2-associated pathology of the small intestine
We have previously generated a mouse model of spontaneous Th2-associated disease of
the small intestine called TRAF6ΔDC, in which dendritic cell (DC)-intrinsic expression of the …
the small intestine called TRAF6ΔDC, in which dendritic cell (DC)-intrinsic expression of the …
The gut bacteria dysbiosis contributes to chronic graft-versus-host disease associated with a Treg/Th1 ratio imbalance
Y Wang, L Huang, T Huang, S Geng, X Chen… - Frontiers in …, 2022 - frontiersin.org
Introduction Dysbiosis of gut bacteria has been discovered in a large number of autoimmune
diseases. However, the influence of the gut bacteria in the mice model of chronic …
diseases. However, the influence of the gut bacteria in the mice model of chronic …
Reducing gut microbiome-driven adipose tissue inflammation alleviates metabolic syndrome
Background The gut microbiota contributes to macrophage-mediated inflammation in
adipose tissue with consumption of an obesogenic diet, thus driving the development of …
adipose tissue with consumption of an obesogenic diet, thus driving the development of …
Interleukin 21 Drives a Hypermetabolic State and CD4+ T-Cell–Associated Pathogenicity in Chronic Intestinal Inflammation
Background & Aims Incapacitated regulatory T cells (Tregs) contribute to immune-mediated
diseases. Inflammatory Tregs are evident during human inflammatory bowel disease; …
diseases. Inflammatory Tregs are evident during human inflammatory bowel disease; …
The association of gut microbiota and Treg dysfunction in autoimmune diseases
Autoimmune conditions affect 23 million Americans or 7% of the US population. There are
more than 100 autoimmune disorders, affecting every major organ system in humans. This …
more than 100 autoimmune disorders, affecting every major organ system in humans. This …
Dysfunction of Foxp3+ Regulatory T Cells Induces Dysbiosis of Gut Microbiota via Aberrant Binding of Immunoglobulins to Microbes in the Intestinal Lumen
K Koshida, M Ito, K Yakabe, Y Takahashi, Y Tai… - International journal of …, 2023 - mdpi.com
Foxp3+ regulatory T (Treg) cells prevent excessive immune responses against dietary
antigens and commensal bacteria in the intestine. Moreover, Treg cells contribute to the …
antigens and commensal bacteria in the intestine. Moreover, Treg cells contribute to the …