Immunobiotics beneficially modulate TLR4 signaling triggered by lipopolysaccharide and reduce hepatic steatosis in vitro

P Kanmani, AZ Ansari, J Villena… - Journal of immunology …, 2019 - Wiley Online Library
Hepatic inflammation and injury may result from the translocation of pathological bacteria
and their proinflammatory mediators. Probiotics attenuate hepatic diseases related to …

Protective effects of lactic acid bacteria against TLR4 induced inflammatory response in hepatoma HepG2 cells through modulation of toll-like receptor negative …

P Kanmani, H Kim - Frontiers in immunology, 2018 - frontiersin.org
The beneficial effects of probiotics in several liver diseases have been investigated in both
animal and clinical models; however, the precise mechanisms responsible for their effects …

Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability

Q Liu, H Tian, Y Kang, Y Tian, L Li, X Kang… - The Journal of …, 2021 - Elsevier
Autoimmune hepatitis (AIH) is an immune-mediated type of chronic liver inflammation
accompanied by intestinal flora imbalance. Probiotics have been reported to ameliorate …

Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia

L Xue, J He, N Gao, X Lu, M Li, X Wu, Z Liu, Y Jin… - Scientific reports, 2017 - nature.com
Gut-derived bacterial lipopolysaccharide (LPS) and subsequent hepatic toll-like receptor 4
(TLR4) activation have been recognized to be involved in the onset of diet-induced …

Probiotic Lactobacillus casei Zhang reduces pro-inflammatory cytokine production and hepatic inflammation in a rat model of acute liver failure

Y Wang, J Xie, Y Li, S Dong, H Liu, J Chen… - European journal of …, 2016 - Springer
Purpose In this study, we sought to find the effects and mechanisms of probiotic
Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and …

Immunobiotic strains modulate Toll-like receptor 3 agonist induced innate antiviral immune response in human intestinal epithelial cells by modulating IFN regulatory …

P Kanmani, H Kim - Frontiers in Immunology, 2019 - frontiersin.org
Many studies have demonstrated that immunobiotics with immunoregulatory functions
improve the outcomes of several bacterial and viral infections by modulating the mucosal …

[HTML][HTML] Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

C Tang, W Zhou, M Shan, Z Lu, Y Lu - Food Science and Human Wellness, 2022 - Elsevier
Accumulating evidence revealed that some probiotics regulated lipid metabolism and
alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored …

Mechanism of TLR4-Mediated Anti-Inflammatory Response Induced by Exopolysaccharide from the Probiotic Bacillus subtilis

J Zamora-Pineda, O Kalinina, AI Sperling… - The Journal of …, 2023 - journals.aai.org
Intestinal inflammatory diseases affect millions of people worldwide, and one class of drugs
showing promise toward treatment of several inflammatory diseases is probiotics. Numerous …

Immunobiotic Bacteria Attenuate Hepatic Fibrosis through the Modulation of Gut Microbiota and the Activation of Aryl‐Hydrocarbon Receptors Pathway in Non …

P Kanmani, J Villena, S Lim, EJ Song… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease
worldwide that can progress to liver fibrosis (LF). Probiotics have beneficial roles in reducing …

Lactiplantibacillus plantarum NKK20 Alleviates High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Regulating Bile Acid Anabolism

C Sun, C Qiu, Y Zhang, M Yan, J Tan, J He, D Yang… - Molecules, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease in modern
society. It is characterized by an accumulation of lipids in the liver and an excessive …