… mechanisms of action of auranofin and analogues are still controversial. Here, we report on
the inhibition effects of glutathione S-transferase P1-1 (GST P1-1) exerted by auranofin. The …

… -based anti-inflammatory compound used for the treatment of … focus mainly on its inhibitory
effects on antioxidant defensive … to the identification of a variety of targets for AUR, and this …

… by gold compounds are mainly the result of potent inhibition of … The antiarthritic gold(I)
phosphine drug, auranofin, was … (PDI), glutathione S-transferase and Escherichia coli DsbA, …

… Auranofin is an antiarthritic gold phosphine compound that … in contrast to other described
targets 103 . Therefore, future … mechanism of enzyme inhibition played by auranofin on GSTs…

… (GR), glutathione-S-transferase, 12 cysteine proteases, 13 … shown to be potently inhibited
by gold complexes. Interestingly, … and cell extracts, in comparison to auranofin, the gold(I) anti-…

… selectively targeted by Trx and GSH inhibitors. Trx and GSH … Conversely, the TrxR inhibitor
auranofin partially inhibits the … compounds, likely via S-nitrosylation (71, 72). Additionally, …

… represent a potential target for colorectal cancer therapy. … -NT substrate and Glutathione
S-Transferase) added to each well of … inhibitor auranofin and aldehyde dehydrogenase inhibitor …

… be their therapeutic targets. For example, auranofin was reported to strongly inhibit two Sec-…
(17, 18) Auranofin was also shown to possess only modest inhibitory effect on glutathione …

… , cysteine protease, and glutathione-S-transferase, and therefore cause … However, auranofin,
a gold(I)-containing compound … Auranofin inhibited Clostridium difficile toxin production and …

… reference compounds (praziquantel, oxamniquine, auranofin … Schistosomal glutathione
s-transferase and sulfotransferase … In (D) yellow spheres are gold molecules from auranofin in …