… novel PDE4 inhibitor, AA6216, … PDE4 inhibitors, would be able to modulate lung fibrosis.
Therefore, this study aimed to investigate the anti-fibrotic effects of AA6216 through its inhibition …

… In this study, we examined the effect of AA6216 on the pulmonary accumulation of …
AA6216 ameliorates lung fibrosis by inhibiting the recruitment of SatMs to the lung and reducing …

… -phosphodiesterase 4 (PDE4)/PDE4B inhibition in treating … Unlike nintedanib, the PDE4
inhibitor AA6216 was found to … Phosphodiesterase 4 inhibition reduces lung fibrosis following …

… Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic …
, prevented a decrease in lung function in patients with idiopathic pulmonary fibrosis. (Funded …

… of AA6216 in a mouse model of bleomycin-induced lung fibrosis and in alveolar macrophages
… Therefore, we hypothesize that AA6216 may reduce skin inflammation by enhancing FLG …

… Phosphodiesterase 4 inhibitors (PDE4i), lysophosphatidic … resulting in architectural distortion
and lung fibrosis [Citation11]. … reducing inflammation is inhibition of phosphodiesterase 4 (…

… So, Epac1 may be responsible for the anti-fibrosis effect in the lung. Moreover, the … AA6216,
also ameliorated pulmonary fibrosis in mice by inhibiting TGF-β release from macrophages. …

… pulmonary fibrotic sequelae after severe acute respiratory … acute respiratory syndrome (SARS)
and Middle east respiratory syndrome (… mechanism of PDE4 inhibitors in reducing emesis. …

… Introduction BI 1015550 is a phosphodiesterase 4 (PDE4) inhibitor … subjects and patients
with idiopathic pulmonary fibrosis (IPF). … Phosphodiesterase 4 inhibition reduces lung fibrosis …

… pathological circumstances macrophages get dysfunctional, and impaired or aberrant
macrophage activities become key features of diseases. For instance, in both fibrosis and cancer, …