Adsorption of irinotecan onto oral adsorbent AST-120 (KremezinTM) for preventing delayed diarrhea

M Hidaka, K Yamasaki, M Okumura, T Ogikubo… - Cancer chemotherapy …, 2007 - Springer
AST-120 (Kremezin) is a prominent oral adsorbent that consists of … To evaluate whether
Kremezin can prevent the diarrheaadsorption characteristics of CPT-11 and its metabolites onto

Mechanisms and emerging strategies for irinotecan-induced diarrhea

S Xu, H Lan, C Huang, X Ge, J Zhu - European Journal of Pharmacology, 2024 - Elsevier
… for the prevention and treatment of delayed diarrhea. We … balance of intestinal absorption
to cause diarrhea. Moreover, … Clomiphene is such an orally activated carbon composed of …

Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis

U Swami, S Goel, S Mani - Current drug targets, 2013 - ingentaconnect.com
AST-120 (Kremezin) is another oral carbonaceous ad… Kremezin has demonstrated
significant adsorption capacity for … Prevention of irinotecaninduced diarrhea by oral sodium …

[HTML][HTML] Rapid deconjugation of SN‑38 glucuronide and adsorption of released free SN‑38 by intestinal microorganisms in rat

A Takakura, A Kurita, T Asahara… - Oncology …, 2012 - spandidos-publications.com
… toxicities of irinotecan hydrochloride (CPT‑11) is delayed‑onset diarrhea. CPT… adsorption
of CPT-11 onto oral adsorbent AST-120 (Kremezin) for the prevention of delayed-onset diarrhea

Chemotherapy-induced diarrhoea

RJ Gibson, AM Stringer - … opinion in supportive and palliative care, 2009 - journals.lww.com
Adsorption of irinotecan onto oral adsorbent AST-120 (Kremezin) for preventing delayed
diarrhea. … An important study on the use of an oral adsorbent to ameliorate irinotecan-induced …

Anti-colorectal cancer chemotherapy-induced diarrhoea: current treatments and side-effects

RM McQuade, JC Bornstein… - … Journal of Clinical …, 2014 - info.openarchivespress.com
… used anti-diarrheal drug and … AST-120 has been found to be safe and well-tolerated,
effective in reducing pain and bloating in nonconstipated IBS sufferers and to ameliorate irinotecan

Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation

K Kailass, D Casalena, L Jenane… - Journal of medicinal …, 2024 - ACS Publications
… ) that has a lower intestinal absorption, thereby reducing the cytotoxicity experienced by the
… for controlling Irinotecan conversion in patients suffering from life-threatening diarrhea as a …

Pain: cancer

AN Davies, A Dickman, C Reid - Schmerz, 2007 - journals.lww.com
… Phase II clinical trial for prevention of delayed diarrhea with cholestyramine/levofloxacin
in the second-line treatment with irinotecan biweekly in patients with metastatic colorectal …

[图书][B] Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease

TJ Velenosi - 2015 - search.proquest.com
AST-120 is a spherical carbon adsorbent, 0.2-0.4 mm in diameter… can include constipation,
nausea and diarrhea; however, the … AST-120 acts by adsorbing gut-derived uremic toxin …

[引用][C] Toxicology and Disease/Cancer Therapy in Reactive Oxygen Species-Mediated Drugs and Treatments

S Guleria