… through BCR and CD40, as well as other environmental cues, directs the B cell down a path
… the quiescent NF B cell and its BCR affinity for cognate antigen, and proposes that antigen-…

… responses, where the B cell depends on signals from helper T … the integration of signals
received by the B cell including via … may facilitate antigen encounter and affinity discrimination. …

… associated with B cell activation and fate decisions, as well … , how is antigen affinity coupled
to BCR signaling and to antigen … Thus, the BCR’s affinity for antigen not only determines the …

… DAG, diacylglycerol; FcγRIIB, low-affinity Fc receptor for IgG; GSK3, … B-cell fate is determined
by the balance between survival and death signals that are initiated through the B-cell …

… the intrinsic BCR signal strength controls the humoral fate of naive B … affinity threshold
is not required for cell entry into early TD humoral immune responses. Our finding that low-affinity …

… govern B cell fate depending on the strength of signaling … antigen-binding affinity [11–14],
or systems where different … To determine whether differences in the affinity of Tg and B …

… of antigen access into secondary lymphoid organs, antigen … of B cell anergy that have
significantly lower Ig-Tg affinity to self-… signals and T cell help, another factor that determines B cell …

… , both dependent on the function of activation-induced cytidine deaminase 12 , lead to the
generation and selection of mutated antigen-specific B cells carrying high-affinity BCRs 2 . …

… early B cell fate in ways that still remain poorly understood. … higher affinity BCR receive a
productive antigen signal with … when relying on antigen binding alone to identify memory B …

… antigen plays a crucial role in B cell activation, and in particular during affinity-maturation,
the process during which high-affinity B … Although the signaling mechanism has not yet been …