… B-cell antigen receptor (BCR). Whereas the combination of Ig H and L chains determines the
antigenic … β allows transduction of a signal inside the cell that directs cell fate. Developing B …

… major routes for memory B cell and high-affinity long-lived plasma … Recent research has
aimed to determine whether BCR affinity has … They found that an affinity-based CD40 signal was …

… on F-actin remodeling but not on tonic BCR signaling. … We also determined the Brownian
diffusion coefficient of BCRs from the … Termination of B-cell probing is sensitive to the affinity …

… B-cell fates, leading to specific physiologic consequences. … BCR affinities for these positively
selecting antigens will be … and BCR signaling in general, it is important to identify both the …

… have intrinsically higher-affinity thresholds for both B cell antigen receptor (BCR) signaling
and antigen gathering as … We determined whether naïve and GC B cells were able to discern …

… in GCs, antigen-binding and downstream signaling of the … may influence B cell survival or
fate specification during affinity … Second, we identify a transcriptionally distinct and clonally …

… antigens and their affinity to the BCR, the presence of co-stimulatory signals can significantly
modulate B cell … surface-tethered antigens and if so, can this determine how antigens are …

… and consolidation of high affinity B-cell memory as it is … to ascertain the impact of different
adjuvants, antigen dose, … the impact of BCR signal strength as encountered on FDCs by …

… establish that B cell follicular exclusion and rapid death in the Tzone is independent of anergy
but dependent on both continual antigen … the nature of signals that promote B cell survival …

… patterns of immune synapse formation to regulate B-cell fate. … antigen-driven selection
produce and preserve high-affinity … population that provides survival signals to antigen-specific B …