… We have provided evidence that signaling through two B cell … by the T cell receptor [43,44]
and by the high affinity IgE Fc … We determined that eventhough B cells from neonatal mice …

… antigen-specific activation of B cell clones, it has become clear that the BCR plays a central
role in determining the fate of B cells even before it encounters … high-affinity antigen or anti-…

… MZ versus follicular B cell fate are key to understanding … cells that secrete high-affinity
antibodies. Some of these plasma … More likely, signaling via high-affinity antibody causes an end …

… BCR signaling and T cell help leads to more rapid affinity … same affinity-determined
probability to internalize another … hypothesize a GC B cell calculates its own fate trajectory in a …

… We find that maximal ASC induction requires at least eight cell … signals. In addition, we define
a path to ASC that reveal an … , and selection pressure for high affinity clones 43,44 . Using …

… self-antigen, and promote survival of the highest affinity B … the selection signals determines
the rate of B-cell proliferation … so that encounter with each subset leads to different B-cell fates. …

… B cell precursor frequency, B cell receptor affinity for antigen, … B cells with higher p:MHC
receive more T FH help signals … frequency, affinity, and avidity in determining B cell outcomes (…

… 4, 5 can increase the affinity of the B cell receptor for antigen in the … induces signaling
cascades that will determine gene … promotes plasma cell over memory B cell fate.11 While high-…

… B cell generation, and in the signals that determine memory versus plasma cell fate during
primary antigen encounter… roles for the affinity of the BCR for antigen and factors derived from …

… The fate of a B cell is determined by the signals it receives via its antigen receptor at any point
of its … , we refer to the global strength of BCR engagement, determined by affinity and the …