… However, this work did not assess whether the lack of IL-4 affected … signals is important in
TLRs' determination of B cell fates. … generation of antibodies by high affinity B cell clones during …

… on the strength of BCR signaling, which is determined by the concentration and avidity of …
, BCR affinity, and the context of self-Ag presentation. Self-Ag like CD90 interact at lower affinity …

… , a signal transduction molecule expressed throughout B-cell … the fate of the GC B cell, it is
essential for affinity maturation of … of the complementarity-determining regions (CDRs; Chapter …

… It also drives elimination of low-affinity and self-reactive B cell … determine whether BAFF
can also deliver survival signals at … signaling molecule, positively regulate early B cell …

… affinity of antigen-specific lymphocytes and ‘optimal’ amounts of … B-cell proliferation and
commitment to plasmablast or GC differentiation pathway ensues, perhaps influenced by signals …

… and testing of B-cell antigen receptor signaling. Failure leads … -determining regions, the
loops that form the antigen-binding … develop high-affinity antibodies of other classes, secondary …

… This binding triggers signals inside the cell that determine its fate – … leading to reduced affinity
maturation and memory cell generation. … We next sought to determine whether the antigen-…

… affinities of IgG-secreting cells we measure in mice immunized against Tetanus Toxoid under
largely varying conditions (antigen … cells for getting the survival signal from T-helper cells, …

… The selective fate of an individual B cell clone depends on … that assess BCR crosstalk with
specific TLRs during B cell … initial priming signals, thereby broadening the range of high-affinity …

… the ability to form low-affinity but significant interactions with major … establish the ground state
upon which both T and B cell … IL-7R signals are crucial for early murine B cell development, …