… An important attribute of Cryptococcus neoformans (Cn) pathogenesis is its ability to enter …
three natural products that prevented Cn from crossing the blood-brain barrier by inhibiting the …

… the blood-brain barrier by inhibiting the virulence factor Mpr1 … the use of novel small-molecule
inhibitors of fungal morpho… secreted metalloprotease, Mpr1, is expressed solely in fungi, …

… targets for anti-virulence discovery in the development of new … following crossing of the
blood–brain barrier (BBB) using … The metalloprotease, Mpr1, engages AnnexinA2 to promote …

… human fungal pathogen, Cryptococcus neoformans through … impair fungal crossing of the
blood–brain barrier without … Diosgenin also inhibits matrix metalloproteinases (eg, MMP-2 …

… a significant inhibition of fungal growth at 37C following … by bacterial and fungal human
pathogens to avoid the immune system … of novel anti-virulence treatments against fungal disease. …

… Cryptococcus neoformans (Cn) and Cryptococcus gattii (Cg) are … from the lungs and crosses
the blood-brain barrier (BBB), … A secreted metalloprotease Mpr1 was recently discovered in …

… Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously … crossing the
blood brain barrier in an in vitro transwell model (90). Extracellular elastinolytic metalloproteinase …

… action of cryptococcal serine proteases, metalloproteases and … organisms such as
Cryptococcus neoformans, which operate … condition that weakens the blood–brain barrier (BBB) …

… In pathogenic fungi like Cryptococcus neoformans, C. albicans, and A. … antivirulence
targets include metalloproteases that allow C. neoformans cells to cross the blood brain barrier …

… Cryptococcus neoformans is an opportunistic fungal pathogen … indeed have antifungal
and antivirulence effects against C. … neoformans to cross the blood brain barrier during …