Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis

CE Orhan, A Önal, Y Uyanıkgil, S Ülker - European journal of pharmacology, 2013 - Elsevier
… theraupetic effect of sirolimus in the relief of pain in rat model of adjuvant-induced arthritis.
The … in the spinal cord of arthritic rats has also been investigated to clarify the mechanism of …

Antihyperalgesic and antiallodynic effect of sirolimus in neuropathic pain and the role of cytokines in this effect

CE Orhan, A Önal, S Ülker - Neuroscience letters, 2010 - Elsevier
… with T lymphocyte inhibitory effects are used in neuropathic pain models. However, sirolimus
has been used orally to treat developing adjuvant arthritic rats, a T-cell mediated rat model, …

The Potency of Alpha Lipoic Acid as Anti Inflammatory on the Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in RAT Model

S Megawati, M Rahmadi, I Susilo… - Folia Medica …, 2016 - repository.unair.ac.id
Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis. …
Evaluation of complete freund’s adjuvantinduced arthritis in a wistar rat model (comparison of …

Metformin synergizes with conventional and adjuvant analgesic drugs to reduce inflammatory hyperalgesia in rats

UB Pecikoza, MA Tomic, AM Micov… - Anesthesia & …, 2017 - journals.lww.com
… Because various arthritic inflammatory disorders are highly … drugs needed to produce
an antihyperalgesic effect of 50% (… (an adjuvant analgesic drug) in a rat model of somatic …

Drug repositioning: playing dirty to kill pain

LFS Bastos, MM Coelho - CNS drugs, 2014 - Springer
sirolimus induces antiallodynic and antihyperalgesic effects in rats subjected to CCI [152]
or adjuvant-induced arthritis [… an antiallodynic effect in a rat model of diabetic neuropathy [173]. …

Sirolimus-loaded biodegradable implants induce long lasting anti-inflammatory and antiangiogenic effects

BL Costa, R de Resende Machado, MRB Paiva… - Journal of Drug Delivery …, 2018 - Elsevier
… (2013) [6] reported that sirolimus decreases the arthritic lesions and paw edema and exhibits
antihyperalgesic and anti-allodynic activities in a model of rat adjuvant-induced arthritis. …

[HTML][HTML] Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review

M Chincholkar - British journal of anaesthesia, 2018 - Elsevier
… determine the effects of gabapentinoids in animal models of … This indicates that the in vivo
antiallodynic effects of chronic … effective in arthritic and neuropathic rats but not normal rats; …

Identification of novel analgesics through a drug repurposing strategy

P Gazerani - Pain Management, 2019 - Taylor & Francis
… exerted antihyperalgesic effects in animal models of arthritis [… an acetic acid-induced
hyperalgesia model [Citation14] and … In rodents, sirolimus is antihyperalgesic both in inflammatory …

Mechanistic insight into the effects of curcumin on neuroinflammation-driven chronic pain

Hasriadi, PW Dasuni Wasana, O Vajragupta… - Pharmaceuticals, 2021 - mdpi.com
… -linked brain disorders in animal models. Curcumin was shown … was used to mimic arthritis
in rats by injecting CFA to the … curcumin with any adjuvants in chronic pain models. Therefore, …

[HTML][HTML] … factor Kappa B/tumor necrosis factor alpha and transforming growth factor beta 1/Smads pathways in rats with cardiac injuries induced by adjuvant arthritis

H Chuanbing, W Lei, L Jian - Journal of Traditional Chinese Medicine, 2016 - Elsevier
… Overall performance in AA rats models the clinical manifestations in RA patients. Injection
of FCA into the toe joints led to an early stage inflammatory response and aggravated TSD. …