CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
J Cai, R Li, X Xu, L Zhang, R Lian, L Fang, Y Huang… - Nature cell …, 2018 - nature.com
… to the fact that autophagy can be tumour suppressive or oncogenic in … lung cancer (NSCLC),
casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning as an autophagy …
casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning as an autophagy …
PTEN in lung cancer: dealing with the problem, building on new knowledge and turning the game around
A Gkountakos, G Sartori, I Falcone, G Piro, L Ciuffreda… - Cancers, 2019 - mdpi.com
… -detectable group confirming the close association of PTEN with CK1α [46]. Another … a
strong synergism and induced PTEN protein expression and autophagy mitigating TKI resistance …
strong synergism and induced PTEN protein expression and autophagy mitigating TKI resistance …
[HTML][HTML] Down-Regulation of Casein Kinase 1α Contributes to Endometriosis through Phosphatase and Tensin Homolog/Autophagy-Related 7–Mediated Autophagy
A Zhou, Q Cai, Y Hong, Y Lv - The American Journal of Pathology, 2021 - Elsevier
… The expressions of CK1α, PTEN, and autophagy-related proteins … of CK1α significantly
boosted the levels of autophagy-related … were suppressed in the presence of siRNA-PTEN. …
boosted the levels of autophagy-related … were suppressed in the presence of siRNA-PTEN. …
USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer
M Zhu, H Zhang, F Lu, Z Wang, Y Wu, H Chen… - Bioscience …, 2021 - portlandpress.com
… CK1α could suppress lung tumor growth by stabilizing PTEN [… USP52 and PTEN, we analyzed
the expression of PTEN in … of various biological processes including autophagy [25], cell-…
the expression of PTEN in … of various biological processes including autophagy [25], cell-…
The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment
S Aquila, M Santoro, A Caputo, ML Panno, V Pezzi… - Cells, 2020 - mdpi.com
… suppression, rather than a stepwise alteration of PTEN levels … 1 (CK1α)-dependent autophagic
mechanism and the tumor-… data of non-small-cell lung cancer (NSCLC) patients. treated …
mechanism and the tumor-… data of non-small-cell lung cancer (NSCLC) patients. treated …
Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer
… PTEN stabilization and activity by preventing PTEN … the CK1α/PTEN/FOXO3a/Atg7 axis
inhibits the growth of A549 NSCLC cells and A549 lung tumor xenografts via inducing autophagy …
inhibits the growth of A549 NSCLC cells and A549 lung tumor xenografts via inducing autophagy …
SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer
Y Lv, W Zhang, J Zhao, B Sun, Y Qi, H Ji… - … and Targeted Therapy, 2021 - nature.com
… and tensin homolog (PTEN) has been shown to promote autophagy in HT-29 … cancer cells,
56 and CK1α could suppress lung tumor growth by stabilizing PTEN and inducing autophagy. …
56 and CK1α could suppress lung tumor growth by stabilizing PTEN and inducing autophagy. …
PTEN/AKT upregulation of TMSB10 contributes to lung cancer cell growth and predicts poor survival of the patients
J Li, S Zhou, H Li, Y Xu, N Zhou… - Bioscience, Biotechnology …, 2021 - academic.oup.com
… PTEN/AKT activation upregulates TMSB10 in lung cancer … Importantly, TMSB10 knockdown
significantly suppressed the … suppressed apoptosis and potentiated EMT in lung cancer …
significantly suppressed the … suppressed apoptosis and potentiated EMT in lung cancer …
Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line
H Behrouj, A Seghatoleslam… - Canadian Journal of …, 2021 - cdnsciencepub.com
… indicate that CK1α inhibition reduces autophagy flux and … -catenin stabilization through AKT
signaling and autophagy in a … the D4476 suppresses autophagy and induces apoptosis in a …
signaling and autophagy in a … the D4476 suppresses autophagy and induces apoptosis in a …
Casein kinase 1α 1 is involved in the progression of glioblastoma through HIF-1α-mediated autophagy
W Nie, X Luo, D Lu, P Yuan, B Liu… - Journal of …, 2022 - journals.physiology.org
… In addition, CK1α inhibition suppresses colorectal cancer and … the impact of CK1α expression
on autophagy-related genes … continuous stabilization and activity due to CK1α binding …
on autophagy-related genes … continuous stabilization and activity due to CK1α binding …