… Today, chemistry offers numerous design opportunities that can be introduced in a … Here,
we will describe the CPP design strategies in four sub-sections with increasing structural …

… by short peptides, especially cell-penetrating peptides (CPPs… often added to amphipathic
peptides as a design strategy, with … of “cell-penetrating peptides” beyond polycationic carrier …

… Synthetic CPPs include model amphipathic peptides and … Beyond hydrophobicity, the aromatic
functional groups of … On the other hand, design strategies should not focus solely on CPPs…

… primary or secondary amphipathic peptides). For instance, MPG and Pep-1 are primary
amphipathic peptides … The modification of the primary structure of a peptide through covalent or …

… peptides is amphipathicity [34]. They can be amphipathic in their primary structure or secondary
structure… Within 3.5 h from its iv administration, the peptide was found beyond the BBB in …

… , structural modifications and novel design strategies have … the acidic amphipathic proline
rich peptide SAP(E) where the basic … Beyond the molecular structure, NMR spectroscopy can …

… This review focuses on the peptide-based strategy for intracellular delivery of CPP-modified …
for the design of ‘smart' pharmaceutical nanocarriers in which the cell-penetrating properties …

… amphipathic peptide which has shown great promise as an efficient, multifunctional delivery
system for the delivery of nucleic acids. Rational peptide design … peptide could be made. Six …

… In summary, the short history of research on cell-penetrating peptides has clearly demonstrated
that CPPs have helped us to expand beyond several long-held dogmas. This presents …

… highly dependent on the helical structure of the peptides and their amphipathicity, in summary,
… A detailed account of the same is beyond the scope of this study and can be found in the …