Cellular receptors, acceptors and clinical implications.

AO Mansilla, RS Argüero, FG Rico… - Archives of medical …, 1993 - europepmc.org
… a specific cell response. Thus, the inductor-receptor binding complex interaction at the cellular
Cellular receptors have been involved in the mechanism of action of several drugs and its …

Stem cell factor receptor/c-Kit: from basic science to clinical implications

J Lennartsson, L Rönnstrand - Physiological reviews, 2012 - journals.physiology.org
… survival, migration, and proliferation depending on the cell type. Signaling from c-Kit is …
targeting this receptor, eg, the clinically used inhibitor imatinib mesylate. Also other clinically used …

Glycosylation in cancer: mechanisms and clinical implications

SS Pinho, CA Reis - Nature Reviews Cancer, 2015 - nature.com
receptors and the modified expression of gangliosides affect cancer cell signal transduction
pathways, modulating tumour cell … the variability of various acceptor substrates as well as the …

The growth hormone receptor: mechanism of activation and clinical implications

AJ Brooks, MJ Waters - Nature Reviews Endocrinology, 2010 - nature.com
… Below the cell membrane, mutation of the splice-acceptor site for exon 8 results in skipping
of exon 9, truncation of the proline-rich box 1 sequence and a dominant negative form of the …

Functional and clinical consequences of mutations in the FSH receptor

J Gromoll, M Simoni, V Nordhoff, HM Behre… - Molecular and cellular …, 1996 - Elsevier
… Beside the transmembrane domain with the typical seven membrane-spanning helices, the
glycoprotein hormone receptors are characterized by a very large extracellular domain in the …

The ubiquitin‐mediated proteolytic pathway: Mode of action and clinical implications

A Ciechanover, A Orian… - Journal of cellular …, 2000 - Wiley Online Library
… pressors such as p53, transcriptional activators and their inhibitors, myc, NF-κB and IκBα,
for example, cell surface receptors such as the growth hormone receptor and the T-…

E-cadherin: Its dysregulation in carcinogenesis and clinical implications

SHM Wong, CM Fang, LH Chuah, CO Leong… - Critical reviews in …, 2018 - Elsevier
cellular functions in the context of carcinogenesis as well as its … ) and methionine (M92) from
the acceptor pocket of E-cadherin … Discoidin domain receptor (DDR) 1 is a receptor tyrosine …

[图书][B] Inorganic biochemistry of iron metabolism: from molecular mechanisms to clinical consequences

RR Crichton, JR Boelaert - 2001 - books.google.com
… ferric iron and transport the ferri-siderophore via a receptor-mediated mechanism into the
microbial cell. The receptors for some of these siderophores were identified genetically as the …

Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting

ES Antonarakis, AJ Armstrong, SM Dehm… - Prostate cancer and …, 2016 - nature.com
… exon of AR-V7) splice acceptor. Further, knockdown of these factors impaired splicing of
exon 3 to CE3 but not exons 3 to 4 in LNCaP95, a cell line derived from the parental LNCaP line …

Thyroid disruption: mechanisms and clinical implications in human health [corrected][published erratum appears in ALTERN MED REV 2010 Apr; 15 (1): 58].

L Patrick - Alternative Medicine Review, 2009 - search.ebscohost.com
… T4 metabolism; and (6) alterations of transport across cellular membranes and alteration
of cellular receptors (TSH receptor). Although these mechanisms reter to animal models, the …