A novel human-specific soluble vascular endothelial growth factor receptor 1: cell type-specific splicing and implications to vascular endothelial growth factor …

S Sela, A Itin, S Natanson-Yaron, C Greenfield… - Circulation …, 2008 - Am Heart Assoc
… intron 14 splice acceptor site, only takes … receptor or 1 of the 2 truncated soluble receptors,
are mutually exclusive. Thus, the highly preferred utilization of the intron 14 splice acceptor in …

Teaching old receptors new tricks: biasing seven-transmembrane receptors

S Rajagopal, K Rajagopal, RJ Lefkowitz - Nature reviews Drug …, 2010 - nature.com
… be due to cell-specific effects and receptor heterogeneity 47 . … In this section, we highlight
the physiological consequences … and an acceptor probe can be attached to the receptor and β-…

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
… Alternatively, cell surface receptors can be activated by specific ligands that bind to “death
receptors.” AIF, apoptosis-inducing factor; Cytc, cytochrome C [Color figure can be viewed at …

The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and …

EW Hillhouse, DK Grammatopoulos - Endocrine reviews, 2006 - academic.oup.com
… mechanisms via paracrine or autocrine activation of specific receptors expressed on the cell
membrane of target cells. These CRH receptors (CRH-Rs) and the mechanisms regulating …

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

JM Matés, JA Segura, FJ Alonso, J Márquez - Archives of toxicology, 2008 - Springer
… agents including electron acceptors, electron donors, and hydride acceptors can be … receptor
superfamily called the death receptors (TNFR1, FAS, and TRAIL). Receptor-mediated cell

Nanomaterials for cancer precision medicine

Y Wang, S Sun, Z Zhang, D Shi - Advanced materials, 2018 - Wiley Online Library
… emerged with specific clinical implications and challenges that … to treat diseases in tissues
with HA receptors, such as liver and … tumor cell uptake has also been found with PGA receptor-…

[HTML][HTML] In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease

CH Lau, Y Suh - F1000Research, 2017 - ncbi.nlm.nih.gov
… In addition, we discuss the clinical implications and potential strategies to overcome off-… to
disrupt both of the endogenous T-cell receptor ( TCR) and beta-2 microglobulin ( B2M) genes. …

Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation

KE Schmid, WS Davidson, L Myatt, LA Woollett - Journal of lipid research, 2003 - ASBMB
cellular cholesterol concentration further increased the amount of cholesterol transported to
the basolateral acceptors… into the cells and effluxed to acceptors in the basolateral chamber. …

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis

MS Brown, JL Goldstein - Annual review of biochemistry, 1983 - annualreviews.org
… to a cell surface receptor. Although macrophages express few receptors for normal plasma …
or excreted from the cell, depending on whether or not a cholesterol acceptor is present in the …

… activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical …

LWT Tang, ECY Chan - Biochemical Pharmacology, 2022 - Elsevier
… which bears profound clinical implications (ie… cellular macromolecules, the likelihood of this
occurring in reality is mitigated by the low intrinsic chemical reactivity of the Michael acceptor