[HTML][HTML] Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole

D Frank, L Schenck, A Koynov, Y Su, Y Li… - Pharmaceutics, 2021 - mdpi.com
prepared in a range of solvents. Following the patent literature [43,44], polymorphs of
posaconazole were prepared … that both originate from solvent-induced plasticization of the ASD. In …

[HTML][HTML] Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development

R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
… processes on the selection and design of amorphous solid dispersion (ASD) products as …
thin film ASD prepared by solvent evaporation. DMA can be used for identification of proper

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

DG Yu, JJ Li, GR Williams, M Zhao - Journal of controlled release, 2018 - Elsevier
ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and …
of the solvent system used for formulation preparation (eg pH adjustment or use of a co-solvent), …

Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions

M Sun, C Wu, Q Fu, D Di, X Kuang, C Wang… - International journal of …, 2016 - Elsevier
… In order to assess the polymers’ ability to maintain the supersaturation of lacidipine, a solvent-…
Preparation of amorphous solid dispersions ASDs were prepared by solvent evaporation. …

Ternary solid dispersions: classification and formulation considerations

S Borde, SK Paul, H Chauhan - Drug Development and Industrial …, 2021 - Taylor & Francis
… and in this review, ASD is used in the same manner. … used to prepare ASDs, namely the
melting and solvent evaporation … Selection of preparation method of TSD based on organic …

The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions

S Dedroog, E Boel, C Kindts, B Appeltans… - International Journal of …, 2021 - Elsevier
… in residual solvent of the spray dried ASDs prepared using diverse solvents, for every solvent,
… The identification of additional solvent selection criteria is not only important to choose an …

Amorphous solid dispersion of ibuprofen: A comparative study on the effect of solution based techniques

A Ziaee, S O'Dea, A Howard-Hildige, L Padrela… - International journal of …, 2019 - Elsevier
… the impact of three different solvent-based processing … and dissolution properties of ASD
formulations of Ibuprofen (IBU… were evaluated for the preparation of ASDs of IBU with polymers …

Solvent-assisted hot melt extrusion of a thermally labile, high melting point compound

C Lagan, JE Huckle, JM Katz, B Khorsand, D Daurio… - AAPS …, 2021 - Springer
… -intensive process, which can become an important deciding factor due to organic solvents
… In this work, a new approach is presented, utilizing HME technology to prepare an ASD of …

Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier

M Koromili, A Kapourani, A Koletti, G Papandreou… - AAPS …, 2022 - Springer
… an appropriate matrix/carrier for the preparation of SDR ASDs… dichloromethane (three times
for each solvent) for at least 48 h … out using mixtures of solvents appropriate for each group of …

Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations

B Démuth, ZK Nagy, A Balogh, T Vigh, G Marosi… - International journal of …, 2015 - Elsevier
good method to prepare an ASD. Besides choosing the appropriate polymer, selection of the
suitable … The tablet consisted of an ASD of simvastatin made by solvent evaporation with a …