Determination of precipitation inhibitory potential of polymers from amorphous solid dispersions

RB Chavan, A Lodagekar… - Drug development and …, 2018 - Taylor & Francis
… a solvent (2:1 ratio) for HPMC and HPC, and methanol for PVP. ASDs of HPMC E3 and HPMC
E50 were prepared in … These observations underscore the fact that selection of polymers …

Manufacturing Amorphous Solid Dispersions With Improved Solid-State Stability

SV Bhujbal - 2021 - hammer.purdue.edu
… low-cost anti-solvent precipitation approach could be an affordable choice to prepare ASDs
of … , the feasibility of preparing ASDs by a combination approach of anti-solvent precipitation …

Myth or truth: The glass forming ability class iii drugs will always form single-phase homogenous amorphous solid dispersion formulations

P Panini, M Rampazzo, A Singh, F Vanhoutte… - Pharmaceutics, 2019 - mdpi.com
… DCM was considered the first choice of solvent in this study … the amorphous state prepared
using solvent based methods. … However, for the ASDs prepared by film casting with PVPVA 64 …

New strategies for improving the development and performance of amorphous solid dispersions

A Haser, F Zhang - Aaps Pharmscitech, 2018 - Springer
… performing better than the equivalent ASD prepared by spray-drying. High … selection of
organic solvent and processing conditions is necessary to achieve a high-quality spray-dried ASD

Development of nimesulide amorphous solid dispersions via supercritical anti-solvent process for dissolution enhancement

G Liu, L Gong, J Zhang, Z Wu, H Deng… - European Journal of …, 2020 - Elsevier
… A selection of the most relevant experiments and corresponding … In this study, NIM-ASDs
were successfully prepared by … A suitable combination of operating conditions for the …

MBP technology: composition and design considerations

N Shah, H Sandhu, DS Choi, H Chokshi, R Iyer… - … solid dispersions: theory …, 2014 - Springer
… In the ASD preparation, polymer and active pharmaceutical … the selection of polymers in
the development of stable ASDs … is adequate solubility in these solvent, other means of ASD

Phase behavior of drug-hydroxypropyl methylcellulose amorphous solid dispersions produced from various solvent systems: Mechanistic understanding of the role of …

NA Mugheirbi, LI Mosquera-Giraldo… - Molecular …, 2018 - ACS Publications
solvent properties on the phase behavior of ASDs containing itraconazole (ITZ) and
hydroxypropylmethyl cellulose (HPMC) prepared … for selecting the proper solvent/solvent mixture …

Preparation and evaluation of amorphous solid dispersions for enhancing Luteolin's solubility in simulated saliva

M Koromili, A Kapourani, P Barmpalexis - Polymers, 2022 - mdpi.com
… the preparation of amorphous solid dispersions (ASD) for the … studied before the selection
of the most suitable ASD matrix/… -PVP ASDs were prepared via the solvent evaporation method…

[PDF][PDF] Understanding colloidal speciation events of ASDs through advanced screening tools

AFD Pereira - 2019 - run.unl.pt
… The ASDs can be prepared by different processes like spray-… Beyond the API properties,
the selection of the adequatesolvent but also due to the high ITZ solubility in this solvent. …

The antisolvent coprecipitation method for enhanced bioavailability of poorly water-soluble drugs

J Zhang, M Liu, Z Zeng - International Journal of Pharmaceutics, 2022 - Elsevier
… (s) are dissolved in a good solvent, and then an antisolvent is … for nanocrystal preparation
is to choose an appropriate … Calvin Sun and coworkers prepared an ASD of sorafenib and …