Phase behavior of drug-hydroxypropyl methylcellulose amorphous solid dispersions produced from various solvent systems: Mechanistic understanding of the role of …
NA Mugheirbi, LI Mosquera-Giraldo… - Molecular …, 2018 - ACS Publications
… solvent properties on the phase behavior of ASDs containing itraconazole (ITZ) and
hydroxypropylmethyl cellulose (HPMC) prepared … for selecting the proper solvent/solvent mixture …
hydroxypropylmethyl cellulose (HPMC) prepared … for selecting the proper solvent/solvent mixture …
Amorphous drug preparation methods
M Rams-Baron, R Jachowicz, E Boldyreva… - … Drugs: Benefits and …, 2018 - Springer
… To select the suitable polymer for defined drug, the following … have been published on ASDs
, successfully prepared by hot-… prepared by co-solvent spray-drying [49]. They found that the …
, successfully prepared by hot-… prepared by co-solvent spray-drying [49]. They found that the …
[HTML][HTML] Preparation and evaluation of amorphous solid dispersions for enhancing Luteolin's solubility in simulated saliva
M Koromili, A Kapourani, P Barmpalexis - Polymers, 2022 - mdpi.com
… the preparation of amorphous solid dispersions (ASD) for the … studied before the selection
of the most suitable ASD matrix/… -PVP ASDs were prepared via the solvent evaporation method…
of the most suitable ASD matrix/… -PVP ASDs were prepared via the solvent evaporation method…
[PDF][PDF] Understanding colloidal speciation events of ASDs through advanced screening tools
AFD Pereira - 2019 - run.unl.pt
… The ASDs can be prepared by different processes like spray-… Beyond the API properties,
the selection of the adequate … solvent but also due to the high ITZ solubility in this solvent. …
the selection of the adequate … solvent but also due to the high ITZ solubility in this solvent. …
Formulation, process development, and scale-up: Spray-drying amorphous solid dispersions for insoluble drugs
B Vig, M Morgen - Developing Solid Oral Dosage Forms, 2017 - Elsevier
… Processing temperatures, miscibility of API and solvent, time spent in … choice of the process
for making ASDs. For example, an API with a high T m can present challenges for preparation …
for making ASDs. For example, an API with a high T m can present challenges for preparation …
Analytical and computational methods for the determination of drug-polymer solubility and miscibility
… a successful selection of stable ASD compositions for … from scans of ASD without preparing
any reference amorphous … , where solvent should rapidly dissolve the ASD components. …
any reference amorphous … , where solvent should rapidly dissolve the ASD components. …
Regulatory considerations in development of amorphous solid dispersions
… These property will dictate the excipients , method, and process selection for ASD product. …
, solvent co-precipitation MBP technology was successfully utilized to prepare a stable ASD of …
, solvent co-precipitation MBP technology was successfully utilized to prepare a stable ASD of …
Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream processing to orodispersible dosage forms
… The characterization of tableting properties has been described for ASDs prepared mostly
… of electrospun ASDs, and can be controlled through solvent and polymer selection (…
… of electrospun ASDs, and can be controlled through solvent and polymer selection (…
Optimizing the formulation of poorly water-soluble drugs
X Ma, D Ellenberger, KP O'Donnell… - Formulating Poorly Water …, 2022 - Springer
… The preparation of an adequate compact for analysis is … Results demonstrated that a
homogenous ASD without phase … 1, 2, and 3 solvents used in pharmaceutical preparations. It …
homogenous ASD without phase … 1, 2, and 3 solvents used in pharmaceutical preparations. It …
Structured development approach for amorphous systems
S Page, R Maurer, N Wyttenbach - Formulating Poorly Water Soluble …, 2016 - Springer
… (ASD), in particular those stabilized with polymers have emerged as a method of choice
for … compositions and drug loads prepared by solvent casting. Amorphous drug films are …
for … compositions and drug loads prepared by solvent casting. Amorphous drug films are …