A rational approach towards development of amorphous solid dispersions: experimental and computational techniques
P Chakravarty, JW Lubach, J Hau… - International Journal of …, 2017 - Elsevier
… of an ASD based on polymer selection by determining its … was employed to remove the
solvent and obtain the lyophilized … method of preparation affects the performance of ASDs. Thus…
solvent and obtain the lyophilized … method of preparation affects the performance of ASDs. Thus…
Structured development approach for amorphous systems
S Page, R Maurer, N Wyttenbach - Formulating Poorly Water Soluble …, 2016 - Springer
… (ASD), in particular those stabilized with polymers have emerged as a method of choice
for … compositions and drug loads prepared by solvent casting. Amorphous drug films are …
for … compositions and drug loads prepared by solvent casting. Amorphous drug films are …
[PDF][PDF] 3 Chapter Three: Amorphous Solid Dispersion of Ibuprofen: A Comparative Study on the Effect of Solution Based Techniques
A Ziaee, S O'Dea, A Howard-Hildige… - Spray drying of … - researchrepository.ul.ie
… solvent-based processing techniques (ES, SD and RE) on the physicochemical properties of
ASDs … showed the significance of preparation technique in altering the critical properties of …
ASDs … showed the significance of preparation technique in altering the critical properties of …
Exploring the feasibility of the use of biopolymers as a carrier in the formulation of amorphous solid dispersions–Part I: Gelatin
T Pas, B Vergauwen, G Van den Mooter - International journal of …, 2018 - Elsevier
… ) suspensions are prepared for subsequent development … polymers, selection of adequate
processing techniques is … In the effort of realizing this, ASD production by a solvent method …
processing techniques is … In the effort of realizing this, ASD production by a solvent method …
Amorphous drug preparation methods
M Rams-Baron, R Jachowicz, E Boldyreva… - … Drugs: Benefits and …, 2018 - Springer
… To select the suitable polymer for defined drug, the following … have been published on ASDs
, successfully prepared by hot-… prepared by co-solvent spray-drying [49]. They found that the …
, successfully prepared by hot-… prepared by co-solvent spray-drying [49]. They found that the …
Regulatory considerations in development of amorphous solid dispersions
… These property will dictate the excipients , method, and process selection for ASD product. …
, solvent co-precipitation MBP technology was successfully utilized to prepare a stable ASD of …
, solvent co-precipitation MBP technology was successfully utilized to prepare a stable ASD of …
Novel supercritical carbon dioxide impregnation technique for the production of amorphous solid drug dispersions: a comparison to hot melt extrusion
… , we produced ASDs without the use of organic solvents and … of choosing, first, a suitable
polymer and, second, a suitable … reports on its use to prepare ASDs within the literature. The …
polymer and, second, a suitable … reports on its use to prepare ASDs within the literature. The …
Oral formulations for preclinical studies: principle, design, and development considerations
Y Gao, C Gesenberg, W Zheng - Developing solid oral dosage forms, 2017 - Elsevier
… percentage, after which the solubility goes downhill with further increase of the good solvent…
used in ASDs will retain or pick up water during formulation preparation and storage. For …
used in ASDs will retain or pick up water during formulation preparation and storage. For …
Excipients for amorphous solid dispersions
… choosing a polymer for ASD, one has to be careful to select … ASD prepared by solvent
method like SD, the drug is dissolved in a solution of the hydrophilic polymer in an organic solvent. …
method like SD, the drug is dissolved in a solution of the hydrophilic polymer in an organic solvent. …
Mesoporous ASD: Fundamentals
A Garcia-Bennett, A Feiler - Amorphous Solid Dispersions: Theory and …, 2014 - Springer
… such as SBA-15 (prepared with polymeric surfactants). In these … The commonly used solvent
in laboratory experiments … the loaded particles by choosing a suitable solvent in which the …
in laboratory experiments … the loaded particles by choosing a suitable solvent in which the …