Citalopram ameliorates impairments in spatial memory and synaptic plasticity in female 3xTgAD mice

Z Wei, G Junhong, N Xiaoyuan, W Jie… - BioMed research …, 2017 - Wiley Online Library
… of citalopram on behavioral performance and synaptic plasticity in female 3xTgAD mice, a
… and exhibits age-dependent deficits in spatial memory and synaptic plasticity [15, 16]. Our …

Differential effects of citalopram on sleep-deprivation-induced depressive-like behavior and memory impairments in mice

A Misrani, S Tabassum, X Chen, S Tan, J Wang… - Progress in Neuro …, 2019 - Elsevier
spatial memory deficits in mice, while subchronic administration of CTM to the S-Dep mice
ameliorates learning and memory deficits (… to S-Dep mice prevented synaptic plasticity deficits. …

Citalopram attenuates tau hyperphosphorylation and spatial memory deficit induced by social isolation rearing in middle-aged rats

QG Ren, WG Gong, YJ Wang, QD Zhou… - Journal of Molecular …, 2015 - Springer
… that citalopram increases the level of melatonin which negatively regulates GSK-3β and
attenuates tau hyperphosphorylation and spatial memory … antidepressants could ameliorate AD-…

Effects of citalopram on neuropsychiatric symptoms in Alzheimer's dementia: evidence from the CitAD study

AK Leonpacher, ME Peters, LT Drye… - American Journal of …, 2016 - Am Psychiatric Assoc
… On the NPI’s agitation domain, the effect of citalopram was no better … citalopram on all
individual domains assessed by the NPI. We hypothesized that individuals treated with citalopram, …

[HTML][HTML] Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice

E Francesca, J Kristina, LL María, H Sarah… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… The impairments in explorative behavior and spatial memory … in regulating synaptic
plasticity and memory formation. We … by citalopram on fear associated memory in female mice

[HTML][HTML] Anxiety and Alzheimer's disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

NC Reyna, BJ Clark, DA Hamilton… - Frontiers in Aging …, 2023 - ncbi.nlm.nih.gov
… , with Tg female mice spending increased … 3xTg-AD mice (12–15 months old) perform
consistently worse on the MWT compared to WT controls, showing severe deficits in spatial memory

[HTML][HTML] Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice

F Eroli, K Johnell, ML Leal, C Adamo, S Hilmer… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
synaptic plasticity and important mediators of many forms of … citalopram and low-dose aspirin
improves deficits in memory … by metoprolol impaired contextual and spatial memory in rats …

Citalopram and its use in sleep-deprivation-induced depression

A Misrani, C Long - The Neuroscience of Depression, 2021 - Elsevier
spatial memory and synaptic plasticity deficits and decrease the levels of insoluble Aβ 40 in
3xTgAD micememory by promoting synaptic plasticity and hippocampal neurogenesis in SD …

Selective serotonin reuptake inhibitors and Alzheimer's disease

B Mdawar, E Ghossoub, R Khoury - Neural regeneration research, 2020 - journals.lww.com
… amyloid and tau deposits in mice, as well as … citalopram in drinking water for 4 months was
also shown to significantly decrease cortical and hippocampal plaque load on autopsy brain

[HTML][HTML] Spatial training ameliorates long-term alzheimer's disease-like pathological deficits by reducing NLRP3 inflammasomes in PR5 mice

QG Ren, WG Gong, H Zhou, H Shu, YJ Wang… - …, 2019 - Elsevier
… and improve memory performance in 3xTg-AD mice [4]. … decreased synaptic plasticity in the
10-month-old PR5 mice. … slices and improved spatial memory in AD transgenic mice [10, 24]. …