Therapeutic potential of resveratrol: the in vivo evidence

JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
… was only after a 1992 report of high levels of resveratrol in red … enzymes that are induced in
a coordinated manner to detoxify … Increases in the expression of both eNOS and iNOS 95 , as …

Resveratrol in cardiovascular disease: what is known from current research?

H Wang, YJ Yang, HY Qian, Q Zhang, H Xu, JJ Li - Heart Failure Reviews, 2012 - Springer
… kinase)/eNOS/NO/vascular endothelial growth factor (VEGF) … Although eNOS plays a role
in the effects of resveratrol, iNOSafter I/R injury, but the beneficial effect of resveratrol was not …

[HTML][HTML] Resveratrol: twenty years of growth, development and controversy

JM Pezzuto - Biomolecules & therapeutics, 2019 - ncbi.nlm.nih.gov
… published nearly 60 years later, resveratrol became a household … but, realistically, resveratrol
has the potential of mediating a … At biomarker levels, resveratrol induced apoptosis and …

Ischemia reperfusion injury in isolated hearts from spontaneously hypertensive rats following chronic resveratrol treatment

K Durham - 2011 - uwspace.uwaterloo.ca
… O2 consumption, and the upregulation of iNOS and eNOS is a … regarding IRI and the
potential for resveratrol to act as a … Interestingly resveratrol treatment did not affect eNOS protein …

Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFκB

S Das, CG Fraga, DK Das - Free radical research, 2006 - search.ebscohost.com
Since NO can induce the expression of heme oxygenase-1 (HO-1), we examined if HO-1 …
potential mechanisms for resveratrol protection of the heart associated to HO-1 induction. We …

Resveratrol: its biologic targets and functional activity

S Pervaiz, AL Holme - Antioxidants & redox signaling, 2009 - liebertpub.com
… through endothelial nitric oxide synthase (eNOS) (439). This … vitro by induction of vascular
endothelial growth factor (VEGF) … Since then, numerous reports investigating the effects of RSV …

Resveratrol improves TNF-α-induced endothelial dysfunction in a coculture model of a Caco-2 with an endothelial cell line

IM Toaldo, J Van Camp, GB Gonzales… - The Journal of nutritional …, 2016 - Elsevier
… increase of VEGF was observed after 4 h of treatment. … Yet, the coculture system has the
potential to mimic the in … to positively induce endothelial nitric oxide synthase (eNOS) activity and …

[HTML][HTML] VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation

C Gentile, RC Muise-Helmericks, CJ Drake - Developmental biology, 2013 - Elsevier
… plus L-NIO, an eNOS inhibitor, or resveratrol, an NO … , we showed that following VEGF
treatment p-eNOS (S1177) levels … to this study exclude a VEGF mediated response through iNOS. …

Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases

I Barbagallo, F Galvano, A Frigiola… - Antioxidants & redox …, 2013 - liebertpub.com
Resveratrol-mediated HO-1 induction has been reported in neuronal cultures and has been
Resveratrol produced significant induction of p-AKT, p-eNOS, Trx-1, HO-1, and VEGF in …

Inhibitory role of resveratrol in the development of profibrogenesis and fibrosis mechanisms

MA Raka, A Tisha, S Khan, TZ Paran… - … & Metabolic Agents …, 2018 - ingentaconnect.com
… -being were observed after Resveratrol supplementation and the … , also up-regulates
eNOSmediated pathway which further … Besides, Ang-II and AT1R interaction may activate VEGF