… quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity
in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFR wt -TK) and three …

… Herein, we report the design, synthesis, and biological evaluation of some novel quinazoline
derivatives. Based on the importance of quinazoline moiety for its anticancer activity, and …

… design and synthesis of two series of 4-pyrrylamino quinazolines as new analogs of the
epidermal growth factor receptor inhibitor … for designing and developing more potent antitumor …

… selective anticancer agents. In this study, three series of quinazoline derivatives bearing a
… -sulfonamide moiety were designed and synthesized as dual EGFR/CAIX inhibitors. All the …

… prompt us to synthesize some new quinazolinones hybridized with … evaluate the anticancer
potential of these novel derivatives, hoping to obtain more potent and selective anticancer …

… for designing novel antitumor agents, we are particularly interested in the present work with
quinazoline derivatives … It is well known that quinazoline derivatives are potent inhibitors of …

… efforts to develop potential antitumor compounds [19] … of quinazoline derivatives with a
benzazepine moiety at the 4-position were designed, synthesized and evaluated as potent EGFR …

… Quinazoline and quinoline derivatives are common targeted inhibitors of EGFR kinase,
and … anticancer drugs. Based on these facts, a series of heterocyclic 2,3-dihydro-[1,4]dioxino[2,3-f]…

… modeling and the biological evaluation were then docked into the binding site of the …
with electron withdrawing groups (eg Cl) as in compound IVc showed higher anti-cancer …

… 6g and 7g exhibited preferable antitumor activity against H1975 cells. Therefore… derivatives
with different aniline substituents at the C-4 position of the quinazoline core on their antitumor …