… study, we evaluated the effects of dimebon upon β-amyloid (Aβ), tau and astrocytes in the
hippocampus of triple transgenic (3xTg-AD) mice, which develop AD-like pathology in an age-…

… Dimebon did not result in amelioration of amyloid pathology, … In 3xTg-AD mice, which express
both mutant AßPP and tau … in coverage were seen in the hippocampus, we found cortical …

… a transgenic mouse model expressing high ß-amyloid levels … but also in mouse cortex,
hippocampus and somewhat less the … indicating that dimebon restores changes of mitochondrial …

… patterns and changes in the nervous system of transgenic mice [18… Further, Dimebon-treated
animals had fewer amyloid deposits … might be linked with its ability to enhance hippocampal …

… Dimebon on formation of pathological protein deposits by examining the disease pattern
development and changes in transgenic mice … level in primary rat hippocampal cells as well as …

… changes in white matter between 3xTg-AD mice and controls, despite well-developed
neurofibrillary tangles and beta amyloid … amyloid immunoreactive plaques in the hippocampus …

… HTZ and HZ mice exhibited hippocampal impairment caused … that amyloid plaques are
deposited in the hippocampal … mouse models, such as 3xTg-AD, which exhibited changes …

… : APP and PS1 genes, a 3xTg-AD mouse model was generated to … ) failed to alter hippocampal
BDNF levels in mice, but this … Drugs, such as Latrepirdine (Dimebon), which was shown to …

… levels of hippocampal TFEB and progress of AD pathology [43]. A … models of mice experience
behavioral changes as well with … that treatment of dimebon in AD transgenic mice lead to a …

… for some of the classic pathological changes observed in … only been conducted in transgenic
mouse models and C elegans, … When dimebon was compared to a placebo group over a 6-…