… (29) Thus, induction of ACD is a possible strategy to … As mentioned above, we identified the
BRD4-AMPK interaction, … to design a small-molecule inhibitor of BRD4 that induces BRD4-…

… be useful for other design approaches and scaffold hopping, and we report novel inhibitors
of BRD4 that have the potential to be developed into significantly more potent compounds. …

… Bromodomain-containing proteins contain domains that specifically recognize histone
acetylation, named “reader”. Among them, the bromodomain and extra-terminal domain (BET) …

… many small-molecule BRD4 inhibitors have been discovered… induction. These indicate that
PROTAC is a more efficient strategy for targeting BRD4 than current small molecule inhibitors…

… Our discovery opens up new opportunities to elucidate the cellular phenotypes … to induce
selective intracellular degradation of their respective target bromodomain-containing proteins. …

… Bromodomain-containing protein 4 (BRD4) is emerging as a therapeutic target that acts
synergistically with other targets of small-molecule … conjugate, can induce BRD4 degradation in …

… Bromodomain protein 4 (BRD4) is the best studied member of the BET family. It is a nuclear
protein that binds to acetylated histone 3 (H3) and histone 4 (H4) tails and plays an essential …

… , the number of small-molecule BET inhibitors has expanded … BRD4 inhibitors can not
only abrogate cytokine-induced … carbon tetrachloride-induced fibrosis in mouse models. (78) …

… of many bromodomain containing proteins has advanced … bromodomains (Brd2, Brd3, and
Brd4). By using a combination … 1b), which shows potent induction of the ApoA1 reporter gene …

… are a total of 61 different bromodomain-containing proteins [3], … to discover the BRD4 inhibitors
by Chung [32]. By analysing … is a positive regulatory component of PTEFb and stimulates …