Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

SR Gilman, J Chang, B Xu, TS Bawa, JA Gogos… - Nature …, 2012 - nature.com
… identify and analyze disease-related gene networks 11,12,13,… of diverse sources of
genome-wide genetic variation under a … the convergence of different types of genetic variations on …

[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
convergent functional genomics (CFG) approach to identify and prioritize genes involved in
schizophrenia, by gene-… environmental component or having a different genetic component. …

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity

J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
… across different studies but also their convergence into a … The identification of convergent
biological pathways involved … in schizophrenia provides a framework for future functional

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

MR Johnson, K Shkura, SR Langley… - Nature …, 2016 - nature.com
… of genes intolerant to functional genetic variation relative to … M3 and schizophrenia but not
with common forms of epilepsy. … and common epilepsy include different gene contributions to …

Towards understanding the schizophrenia code: an expanded convergent functional genomics approach

H Le‐Niculescu, Y Balaraman, S Patel… - … of Medical Genetics …, 2007 - Wiley Online Library
… candidate genes than the genes that still change during co-… surveyed gene expression
changes across six different brain … potentially implicated in the pathophysiology of schizophrenia

[HTML][HTML] Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia

X Chang, LA Lima, Y Liu, J Li, Q Li, PMA Sleiman… - … in genetics, 2018 - frontiersin.org
… Among the different types of gene networks, protein-protein interaction (PPI) networks have
… We hypothesize that a group of functionally related genes with nominal significance could …

Identifying gene regulatory networks in schizophrenia

SG Potkin, F Macciardi, G Guffanti, JH Fallon, Q Wang… - Neuroimage, 2010 - Elsevier
… , induced by genetic variations in the coding or regulatory … inferred from prefrontal cortex
gene expression in 42 different … component of a schizophrenia-related gene network. In support …

Convergence and divergence in the genetics of psychiatric disorders from pathways to developmental stages

S Shohat, A Amelan, S Shifman - Biological psychiatry, 2021 - Elsevier
… risk factors for major neuropsychiatric disorders (schizophreniafunctional convergence
most relevant to a specific condition will likely be shared across different types of genetic variants

[HTML][HTML] Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls

M Mistry, J Gillis, P Pavlidis - BMC neuroscience, 2013 - Springer
… results that converge with existing evidence from genetic and … In general, gene networks
can be analyzed to identify higher-… , genetic variants and haplotypes are also implicated in …

Genetic identification of brain cell types underlying schizophrenia

NG Skene, J Bryois, TE Bakken, G Breen, JJ Crowley… - … genetics, 2018 - nature.com
… in knowledge about the genetic basis of schizophrenia have not converged on findings …
diverse gene sets previously associated with schizophrenia (genes involved in synaptic function