[HTML][HTML] Pharmacological inhibition of Factor XIIa attenuates abdominal aortic aneurysm, reduces atherosclerosis, and stabilizes atherosclerotic plaques

AK Searle, YC Chen, M Wallert… - Thrombosis and …, 2022 - thieme-connect.com
… a novel approach to inhibit atherosclerosis and AAA by treating both … that inhibition of FXIIa
with 3F7 has a protective effect in … Dual inhibition of prothrombotic and inflammatory pathways

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

U Förstermann, N Xia, H Li - Circulation research, 2017 - Am Heart Assoc
… by vascular oxidative stress and inhibited by endothelial NO. … The protective role of Nox4
against atherosclerosis may be … Double knockout (DKO) mice deficient in nNOS and ApoE …

Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway

BK Son, K Kozaki, K Iijima, M Eto, T Kojima… - Circulation …, 2006 - Am Heart Assoc
disease. It is reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase
inhibitors (statins) inhibited vascular … exhibit various protective effects against atherosclerosis, …

[HTML][HTML] The role of statins in vascular disease

PE Laws, JI Spark, PA Cowled, RA Fitridge - European journal of vascular …, 2004 - Elsevier
… Cellular pathways inhibited by statins are boxed. … Meta-analysis of randomised,
placebo-controlled double blind trials … all patients with clinically overt atherosclerotic cardiac …

Molecular mechanisms of vascular effects of high‐density lipoprotein: alterations in cardiovascular disease

C Besler, TF Lüscher, U Landmesser - EMBO molecular medicine, 2012 - embopress.org
… indicative of a potential protective mechanism (ie increased … ‐related pathway that may lead
to potential pro‐atheroscleroticpatients with CAD led to an inhibition of signalling pathways

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

AC Newby - Physiological reviews, 2005 - journals.physiology.org
… proteolytic pathways (136). A study of balloon angioplasty to the … in atherosclerotic primates,
a broad spectrum MMP inhibitor was infused into animals for 28 days to achieve inhibitory

Actions of “antioxidants” in the protection against atherosclerosis

ME Lönn, JM Dennis, R Stocker - Free Radical Biology and Medicine, 2012 - Elsevier
… of oxidative processes in atherosclerosis and its resulting cardiovascular disease by focusing
… be dissociated from atherosclerosis. ► Antioxidants inhibit atherosclerosis by means other …

Inflammation and atherosclerosis: novel insights into plaque formation and destabilization

G Stoll, M Bendszus - Stroke, 2006 - Am Heart Assoc
… −/− mice reversed this protection and increased atherosclerotic lesion … during atherogenesis
is a double-edged sword with a … 123 inhibited the angiotensin II pathway with irbesartan in …

[HTML][HTML] Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management

M Waiz, SS Alvi, MS Khan - EXCLI journal, 2022 - ncbi.nlm.nih.gov
… leading to the arterial atherosclerotic plaque formation. The … It took almost half of a century
after the complex pathway of HMG-R-… a protective effect against atherosclerosis and fatty liver …

Sphingolipids in atherosclerosis and vascular biology

S Chatterjee - Arteriosclerosis, thrombosis, and vascular biology, 1998 - Am Heart Assoc
… Ox-LDL may have a dual role in atherosclerosis. First, low levels of … The inhibition of this
pathway was bypassed by the … 75 In addition, the protective role of trimethylsphingosine of the …