… we describe the synthesis of the C, C,, AB-spiroketal and C,,-… CD-spiroketal altohyrtin
subunits, which will be joined … Multiple deprotection and spiroketalization of this substrate was …

… This is particularly evident in systems containing a hydroxyl group and a spiro CO bond in
a … spongistatin 2 and altohyrtin C are identical compounds and speculate that the altohyrtin …

… highly stereocontrolled total synthesis of the most active congener, altohyrtin A/spongistatin
1 (… Throughout our synthesis, asymmetric boron aldol reactions of ketones are exploited as a …

… that spongistatin 2 and altohyrtin C are identical compounds. The resulting implication was
that the altohyrtin and spongistatin … He confirmed the accessibility of the spiro compound 101 …

… potent antineoplastic macrocyclic lactone spongistatin 1 (1a) … subsequently recognized to be
identical to spongistatin 4 (1b)10. … Although several macrolide antibiotics featuring one spiro …

… 1, our retrosynthetic analysis for spongistatin 1 (1) is based … the CIS-CI6 bond linking the two
spiro acetal ring systems. We … for achieving remote asymmetric induction in the synthesis of …

… synthesis of the CD subunit of spongistatin 1 (altohyrtin A). A … Successful preparation of
the [4.5]-spiro-THP system … reductive cyclization of allylic ethers for the formation of spiro-THP …

… of such structures assumed that the configuration of the spiro … on the total synthesis of
spongistatin 1/altohyrtin A in 2001 [25]… developed for the asymmetric synthesis of C 15 polyketides …

… synthesis of the C29–C51 fragments of spongistatin 114 and has developed a noniterative
approach to the asymmetric synthesis of … of AB15 and CD16 spiroacetals of spongistatin 1–3 …

The C 16 C 28 ketone 3, containing the CD-spiroacetal of spongistatin 1 (1), was prepared
in … Both thermodynamic and kinetic conditions were explored for controlling the CD-acetal …