[HTML][HTML] Estimating risk of antidepressant withdrawal from a review of published data

MA Horowitz, A Framer, MP Hengartner, A Sørensen… - CNS drugs, 2023 - Springer
… of antidepressant withdrawal from the existing literature on the subject. From this review,
we develop a preliminary risk calculator to estimate the risk of withdrawal symptoms in a given …

Predicting relapse after antidepressant withdrawal–a systematic review

IM Berwian, H Walter, E Seifritz, QJM Huys - Psychological medicine, 2017 - cambridge.org
… First, they found that relapse risk was higher after discontinuing antidepressants with larger
effects on the serotonergic or noradrenergic system. Since most studies in this review used …

[HTML][HTML] A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?

J Davies, J Read - Addictive behaviors, 2019 - Elsevier
… We recommend that UK and USA guidelines on antidepressant withdrawal be urgently …
duration of withdrawal in the studies reviewed, thus rendering our overall estimates conservative. …

[HTML][HTML] Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis

J Henssler, Y Schmidt, U Schmidt, G Schwarzer… - The Lancet …, 2024 - thelancet.com
… Subtracting non-specific effects, we estimate the frequency of antidepressant discontinuation
symptoms to be in the range of approximately 15%, thus affecting about one in six to seven …

[HTML][HTML] Withdrawal syndrome following discontinuation of 28 antidepressants: pharmacovigilance analysis of 31,688 reports from the WHO spontaneous reporting …

C Gastaldon, G Schoretsanitis, E Arzenton, E Raschi… - Drug Safety, 2022 - Springer
… We performed three analyses: first, the main disproportionality analysis estimating the
ROR and IC of antidepressant-related withdrawal syndrome as compared to all other drugs …

Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration

M Stone, T Laughren, ML Jones, M Levenson… - Bmj, 2009 - bmj.com
… In contrast with the results of the review of paediatric studies on suicide and antidepressants
by the US Food and Drug Administration (FDA),4 pooled estimates for the adult population …

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database

C Coupland, T Hill, R Morriss, A Arthur, M Moore… - bmj, 2015 - bmj.com
… Cox proportional hazards models were used to calculate … the analysis we calculated
unadjusted and adjusted analysiswithdrawal periods would be attributed to the antidepressant. …

[HTML][HTML] Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis

M Kato, H Hori, T Inoue, J Iga, M Iwata, T Inagaki… - Molecular …, 2021 - nature.com
… Although continuing maintenance therapy with antidepressants is generally recommended,
… to prescribe the antidepressant used to achieve remission. In this meta-analysis, the risk of …

Withdrawal confounding in randomized controlled trials of antipsychotic, antidepressant, and stimulant drugs, 2000–2017

AM Récalt, D Cohen - Psychotherapy and psychosomatics, 2019 - karger.com
calculating whether ≥50% of the difference in relapse risk … groups is present at discontinuation
time points (DCTs) with “… to occur, we reviewed additional literature on antidepressants, …

Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports

T Sharma, LS Guski, N Freund, PC Gøtzsche - bmj, 2016 - bmj.com
estimated accurately. In adults there was no significant increase in all four outcomes, but in
children and adolescents the risk … , access to anonymised individual patient data is needed. …