Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production

MHJ van den Bosch, YFM Ramos… - …, 2019 - academic.oup.com
… elucidate genome-wide molecular profiles of cartilage and bone during … are known to be
differentially methylated during OA, we … This shows that the expression of WISP1 appeared to be …

[HTML][HTML] The role of inflammation-related genes in osteoarthritis

EL Rogers, LN Reynard, J Loughlin - Osteoarthritis and cartilage, 2015 - Elsevier
… , fat pad and subchondral bone contain multiple cell types, … both the candidate gene and
genome-wide approaches, and … clusters based on the differential methylation of inflammation-…

[HTML][HTML] Genetics and epigenetics of bone remodeling and metabolic bone diseases

L Oton-Gonzalez, C Mazziotta, MR Iaquinta… - International Journal of …, 2022 - mdpi.com
… onset of bone metabolic diseases, including osteoporosis [43… Two genome-wide studies
characterized the chromatin landscape … data revealed the involvement of circRNAs in bone

Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease

B Cheng, C Wu, W Wei, H Niu, Y Wen, C Li… - Bone & Joint …, 2024 - boneandjoint.org.uk
… constructed DNA methylation profiles of KBD, osteoarthritis, … Paired differentially methylated
region (DMR) analyses were … the first genome-wide RRBS of peripheral blood to reveal the …

Epigenetics, bone remodeling and osteoporosis

S Yang, X Duan - Current stem cell research & therapy, 2018 - ingentaconnect.com
… the genome wide methylation profile between 27 osteoporosis patients and 26 … Genome-wide
profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

[HTML][HTML] Severity of idiopathic scoliosis is associated with differential methylation: An epigenome-wide association study of monozygotic twins with idiopathic scoliosis

PM Carry, EA Terhune, GD Trahan, LA Vanderlinden… - Genes, 2021 - mdpi.com
… in our dataset was correlated with methylation in bone tissue, … potential roles in fracture
healing and osteoarthritis [109]. The … and extremely small genome-wide discovery analyses. Mao …

[HTML][HTML] Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in …

TG Lien, Ø Borgan, S Reppe, K Gautvik, IK Glad - BMC medical genomics, 2018 - Springer
… This paper aims to identify genome-wide DNA-methylation sites … using controls with hip
osteoarthritis. The authors identified … In addition, we extract differentially methylated CpGs …

[HTML][HTML] Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis

L Yang, J Sun, Y Zhang, X Guo, G Zhao - Frontiers in Genetics, 2022 - frontiersin.org
… of the present study revealed the main histopathological … profiling study identified 972
DEGs in OA subchondral bone … polymorphisms with osteoporosis in postmenopausal women…

[HTML][HTML] Identification of biomarkers associated with diagnosis of postmenopausal osteoporosis patients based on bioinformatics and machine learning

X Huang, J Ma, Y Wei, H Chen, W Chu - Frontiers in Genetics, 2023 - frontiersin.org
… in patients with knee osteoarthritis were higher than those in the … expression in postmenopausal
osteoporosis bone tissues … RBCK1 were identified as differentially methylated genes. All …

[HTML][HTML] Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine …

X Zhou, L Zhao, Z Zhang, Y Chen, G Chen… - BMC Musculoskeletal …, 2024 - Springer
… risk of falls, and diminished bone density. This study aimed to … In this study, instrumental
variables at the genome-wide … and suppresses inflammation in osteoarthritis by targeting PDP1 […