GlgA plays an important role in the induction of hydrosalpinx by Chlamydia muridarum

C Hu, H Wu, Y Sun, J Kong, LL Shao… - Pathogens and …, 2020 - academic.oup.com
… of GlgA deficiency on hydrosalpinx induction in mice. We selected two C. muridarum strains
with GlgAmuridarum. The two mutant isolates had different site mutations that would lead to …

Tryptophan residue of plasmid-encoded Pgp3 is important for Chlamydia muridarum to induce hydrosalpinx in mice

Y Huang, H Wu, Y Sun, Y Liu - Frontiers in Microbiology, 2023 - frontiersin.org
… Pgp3 and GlgA protein expression … GlgA expression (Figure 2). However, although Pgp3
immunoactivity was detected in cultures infected with Pgp3Y197A or Pgp3W234A C. muridarum

Induction of Protective Immunity against Chlamydia muridarum Intravaginal Infection with a Chlamydial Glycogen Phosphorylase

Z Li, C Lu, B Peng, H Zeng, Z Zhou, Y Wu, G Zhong - PloS one, 2012 - journals.plos.org
… but not overall incidence of hydrosalpinx. The GlgP-induced partial protection against upper
… proteins), TC0181 (glycogen synthase or GlgA), TC0257 (glycogen branching enzyme or …

The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract

L Shao, T Zhang, J Melero, Y Huang, Y Liu… - Infection and …, 2018 - Am Soc Microbiol
muridarum strains did not induce hydrosalpinx or spread to the GI tract even when delivered
to … muridarum glycogen synthase A (GlgA) mutants were used in the current study. These …

Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

Y Liu, Y Huang, Z Yang, Y Sun, S Gong… - Infection and …, 2014 - Am Soc Microbiol
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been …
glgA expression and glycogen synthesis (22, 23, 32), we compared the expression of the GlgA

The Chlamydial Plasmid Promotes the Genital Tract Pathogen to Colonize the Mouse Gastrointestinal Tract

JG Melero - 2017 - search.proquest.com
muridarum was enabled to induce hydrosalpinx in some strains of mice including CBA/1J
(29), demonstrating a critical role … on separate groups of mice using the 3 GlgA-deficient C. …

A chlamydial plasmid-dependent secretion system for the delivery of virulence factors to the host cytosol

L Lei, C Yang, MJ Patton, M Smelkinson, D Dorward… - Mbio, 2021 - Am Soc Microbiol
role of GlgA in chlamydial pathogenesis remains poorly defined, nonisogenic Chlamydia
muridarum strains with GlgA … Expression of GlgA/His fusion protein was induced with isopropyl-…

Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum

L Lei, J Chen, S Hou, Y Ding, Z Yang, H Zeng… - Infection and …, 2014 - Am Soc Microbiol
necessary to induce hydrosalpinx, which is consistent with the observation that epithelial cells
actively infected with chlamydial … 20 other genes, including glgA, at the transcription level (…

Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression

Y Liu, C Chen, S Gong, S Hou, M Qi, Q Liu… - Journal of …, 2014 - Am Soc Microbiol
Chlamydia muridarum, which naturally infects mice, can induce hydrosalpinx in mice, a …
chromosomal genes glgA (CTL0167 or CT798 in serovar D of C. trachomatis and TC0181 in C. …

The Role of Chlamydial Colonization of the Gastrointestinal Tract in the Development and Persistence of Chronic Chlamydial Infections

NE Bondareva, EA Koroleva… - … Genetics, Microbiology and …, 2018 - Springer
… without causing a significant pathology, but still inducing chronic … in glycogen synthesis,
including glgA, whereas Pgp5 acted as … of the pyosalpinx and hydrosalpinx with the subsequent …