Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins

K Huang, A Yanai, R Kang, P Arstikaitis, M Metzler… - Neuron, 2004 - cell.com
… that huntingtin-interacting protein, HIP14, is a neuronal palmitoyl transferase involved in the
palmitoylation of … We also show that HIP14 modulates palmitoylation-dependent vesicular …

Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles

T Ohyama, P Verstreken, CV Ly, T Rosenmund… - The Journal of cell …, 2007 - rupress.org
… through palmitoylation regulates protein localization and … palmitoyl transferase
Huntingtin-interacting protein 14 (HIP14… of the exocytic defects associated with the loss of hip14

… -interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated …

RS Stowers, EY Isacoff - Journal of Neuroscience, 2007 - Soc Neuroscience
… In mammalian neurons, we also find a significant fraction of HIP14 colocalizing with a … of
the palmitoyl transferase HIP14 within the presynaptic nerve terminal, we propose palmitoylation

Palmitoylation of huntingtin by HIP14is essential for its trafficking and function

A Yanai, K Huang, R Kang, RR Singaraja… - Nature …, 2006 - nature.com
palmitoylation and distribution of htt are regulated by the palmitoyl transferase huntingtin
interacting protein 14 (HIP14… by palmitoylation, raised the possibility that HIP14 is involved in htt …

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

K Huang, SS Sanders, R Kang… - Human Molecular …, 2011 - academic.oup.com
… dysfunction associated with HD. In … huntingtin-interacting protein 14 (HIP14 or DHHC-17),
which palmitoylates HTT ( 3 , 8 ). Accumulating evidence suggests that aberrant palmitoylation

Aberrant palmitoylation in Huntington disease

SS Sanders, MR Hayden - Biochemical Society Transactions, 2015 - portlandpress.com
… At the same time in a screen for interactors of HTT, Huntingtin interacting protein 14 (HIP14, …
between interactors of HIP14 and interactors of HTT further implicated the HIP14-HTT …

Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase

CE Ducker, EM Stettler, KJ French, JJ Upson, CD Smith - Oncogene, 2004 - nature.com
involvement of HIP14 and protein palmitoylation in cellular transformation and tumor formation.
We can also determine if HIP14 … diseases, HIP14 will be upregulated and involved in the …

Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport

A Goytain, RM Hines, GA Quamme - Journal of Biological Chemistry, 2008 - ASBMB
… of palmitoylation with 2-bromopalmitate, or deletion of the DHHC motif HIP14ΔDHHC,
diminishes HIP14-… GODZ protein acyltransferase is implicated in palmitoylation and regulated …

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

SL Butland, SS Sanders, ME Schmidt… - Human molecular …, 2014 - academic.oup.com
… that reduced palmitoylation of HTT and other HIP14 substrates … One of these is with
Huntingtin Interacting Protein 14 (HIP14, … HIP14 has been implicated in the pathogenesis of HD …

Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L

SS Sanders, KKN Mui, LM Sutton, MR Hayden - PloS one, 2014 - journals.plos.org
… ) and Huntingtin Interacting Protein 14-like (HIP14L) are palmitoyl … fatty acids to proteins in
a process called palmitoylation. … Third, as HTT has been shown to be involved in trafficking of …