… modulates the invasion activity of HCC under tumor hypoxia including HIF-… tumor hypoxia
accelerates cancer invasion by upregulating the expression of ETS-1 and MMPs in HCC cells…

… (Figure 1), we examined the levels of EMT markers and MMPs … to boost HCC cell proliferation
through upregulation of Six1 … of HDAC5 in accelerating the EMT of HCC cells, as shown by …

… phenotype of HCC cell lines through upregulation of HIF1-… ECM remodeling serves a crucial
role in tumor invasion and … are regulated by hypoxia and HIFs, including MMPs, procollagen …

… through downregulating E‐cadherin 7 or upregulating MMP‐2, 8 but few studies have been
… mimic tumor hypoxic microenvironment and analyzed the expressions of E‐cadherin, MMP‐2…

… were significantly upregulated in hypoxic PK8 cells at the … of MMP-2, MT1-MMP and c-Met
elevation in hypoxic PK8 cells. … HGF was reported to stimulate HIF-1 activity in HCC cell lines,…

… hypoxic conditions promoted cell migration via upregulation of … may accelerate cell invasion
through regulation of MMP-7 … of MMP-7, resulting in MMP-7 secretion and HCC cell invasion …

… MT1-MMP expression and invasion of bone … cancer cell invasion and the molecular
mechanisms. Herein, we demonstrate that hypoxia induces Snail expression, thereby upregulating …

… matrix metalloproteinases (MMPs) 1 and 2 were critical in HIF-1α-induced invasion. Mechanistic
… enhances lung cancer cell invasion at least through up-regulating the expression and …

… -1 promotes cell proliferation and accelerates the cell cycle … transcription factor upregulating
the expression of MMPs in both … -1 inhibits cellular metastasis through alteration of invasion-…

… [3], induce angiogenesis [4], accelerate invasion [5] and is … have revealed hypoxia can
upregulate the expression of PDGFA [10], … MMPs increase HCC invasion and growth through the …