… In summary, the following are the key mechanisms that should constitute the basis for the
design of intervention therapies: (1) chondroprotective, (2) anti-inflammatory, (3) matrix …

… advance our understanding of OA pathways as a whole. Several … Finally, we will discuss the
evolving concepts and future … -medicine can play key diagnostic and therapeutic roles in the …

… This review excluded all studies that described inflammatory pathways as an onset of OA …
Further key pathways to prevent PTOA were recently summarized by Chubinskaya et al (15). …

… post-traumatic phases and in PTOA, and (ii) to identify key … Lastly, we discuss beneficial
infrastructure for future studies … , alternative and lectin complement pathways, are activated …

… anabolic and catabolic pathways, regenerative factors, and … vector is one key to successful
gene therapy. Many vectors – … small molecule-based drugs as well as for therapeutic nucleic …

… pharmacological treatments to stop excessive posttraumatic … pathways in osteoprogenitors
and mesenchymal stem cells. Some small molecules also target chronic osteoarthritis (OA) …

… We concluded that the activation of the necroptotic pathway might … target for future therapeutic
strategy in OA disease. … experiments, but future approaches, including more “key players” …

… is a therapeutic target for posttraumatic osteoarthritis. … Our foundational studies suggest that
targeting this pathway is effective … Future studies should interrogate longitudinal changes in …

… future studies on developing non-invasive intervention therapies for cartilage injury post-traumatic …
An up-regulation of these cytokines trigger catabolic pathways the promote production …

… , to inform future basic and translational OA research. … or intraarticular fractures, causing
post-traumatic osteoarthritis (PTOA). … molecules that affect several key pathways or activities. For …