… surrogate for use in clinical studies of PBC. We sought to investigate how serum alkaline
phosphatase and bilirubin levels … their utility as robust surrogate end points for therapeutic PBC …

… increased the ability to predict patient survival times. We confirmed the predictive value of
alkaline phosphatase and bilirubin levels in multiple subgroups, such as patients who had not …

… however, it fails to benefit all patients equally. We agree that bilirubin and alkaline phosphatase
have not been validated fully as true surrogate endpoints. In bringing together the Global …

… The normalization of bilirubin prompted by UDCA has been associated with improved … ,
bilirubin and alkaline phosphatase (ALP) have been established as surrogate endpoints that are “…

… surrogate endpoint for the long-term prognosis in primary biliary cirrhosis (PBC) is highly
desirable. This study evaluated the utility of serum alkaline phosphatase (ALP) and bilirubin. …

… this table are: (1) alkaline phosphatase (ALP) was used in all … was (part of) the primary outcome
measure; (2) histology was … rise in bilirubin may likely not reflect longterm outcome in this …

… a clinical trial on “hard” endpoints is challenging. To this effect, all … surrogate endpoints
that associate with longer-term outcome, and that reflect clinically meaningful benefit to patients…

… (AST), gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (AP)] were the most
… The authors therefore introduced a new criterion (peak bilirubin >7.0 mg/dl) that should be …

… Data on patients that did not reach an end point were … covariates (initial levels of ALP,
AST, total bilirubin and Mayo … Whilst the Mayo risk score has been validated as a surrogate …

… Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients
with primary biliary cirrhosis: an international follow-up study. Gastroenterology 2014; 147:…