Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT …

W Liu, M Yu, D Xie, L Wang, C Ye, Q Zhu, F Liu… - Stem cell research & …, 2020 - Springer
… could endow MSC-derived exosomes with better biological effects, increasing the ratio of
M2 polarization to M1 polarization, thereby inhibiting inflammation and promoting tissue repair. …

Effect of melatonin for regulating mesenchymal stromal cells and derived extracellular vesicles

ZY Feng, SD Yang, T Wang, S Guo - … in Cell and Developmental …, 2021 - frontiersin.org
… , and fatigue in the type 2 diabetes mellitus rat model. Melatonin … shown to significantly
accelerate wound healing. Wnt4 from … Further research is needed to apply MSC-derived exosome

Melatonin and the programming of stem cells

R Hardeland - International Journal of Molecular Sciences, 2022 - mdpi.com
… In summary, the fate and regulation of HSPC descendants cannot … MSC-derived exosomes
are of particular interest, because … Melatonin-stimulated exosomes originating from ADMSCs …

Exosomes and melatonin: Where their destinies intersect

AA Novais, LGA Chuffa, DAPC Zuccari… - Frontiers in …, 2021 - frontiersin.org
exosomes, with a reduction in the intensity of the infarction and an improvement in recovery
through the regulation … , acute inflammatory colitis, diabetes-related wound healing, vascular …

[HTML][HTML] Melatonin pre-treated bone marrow derived-mesenchymal stem cells prompt wound healing in rat models

AM Al-Otaibi, AS Al-Gebaly, R Almeer… - Biomedicine & …, 2022 - Elsevier
… that secreted into ECM and regulate wound healing, tissue … to endorse wound healing in
diabetic mice through protection … -mediated wound healing via increasing the antioxidant …

Melatoninstimulated exosomes enhance the regenerative potential of chronic kidney disease‐derived mesenchymal stem/stromal cells via cellular prion proteins

YM Yoon, JH Lee, KH Song, H Noh… - Journal of pineal …, 2020 - Wiley Online Library
… , atherosclerosis, aging, and diabetes.1, 2 Although kidney … C in MSC-derived exosomes,
suggesting that exosomal PrP C … regulates the expression of PrP C in MSC-derived exosomes, …

[HTML][HTML] Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing

J Wu, LH Chen, SY Sun, Y Li, XW Ran - World Journal of Diabetes, 2022 - ncbi.nlm.nih.gov
MSC-derived exosomes (MSC-Exos) inherit the powerful … BMSC-Exos, while melatonin-stimulated
BMSC-Exos (MT-Exos… in regulating this mechanism to promote wound healing[126]. …

Emerging antioxidant paradigm of mesenchymal stem cell-derived exosome therapy

C Xia, Z Dai, Y Jin, P Chen - Frontiers in Endocrinology, 2021 - frontiersin.org
… can significantly enhance the healing of diabetic wounds. At … has shown that MSC-derived
exosomes can induce … found that MSC-derived exosomes can regulate the function …

Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage

Z Zhou, R Wang, J Wang, Y Hao, Q Xie… - Frontiers in …, 2022 - frontiersin.org
… of exosomes in chronic kidney disease, diabetic wound healing, … Up to now, how to regulate
exosomes release without … therapeutic approaches of MSC-derived exosomes in colorectal …

… -Pretreated Mesenchymal Stem Cell-Derived Exosomes Alleviate Cavernous Fibrosis in a Rat Model of Nerve Injury-induced Erectile Dysfunction via miR-145-5p/TGF …

X Zhang, M Yang, X Chen, M Zhang, Y Peng, M Lu - 2024 - researchsquare.com
MSC-derived EVs exert therapeutic effects while avoiding … can also regulate MSCs behavior
and significantly enhance the … that exosomes isolated from melatonin-stimulated MSCs can …