… of NTG in mice elicits hind paw allodynia, light aversion, and … To test itch responses, mice
received 10 μg serotonin (5-HT) … Adult male mice (wild-type Swiss Webster and heterozygous …

… on oral triptans, 5-HT1B/D receptor agonists that were developed … Wild-type mice also
displayed these CGRP-induced … However, whether these same neurons are modulated by CGRP …

… CGRP this modulation is not limited to the nervous system. … reporter genes in cell cultures
and transgenic mice. A 1.7-kb 5… Serotonin receptor (5-HT 1B/D/F ) agonists that include triptan …

… CGRP-induced diarrhea in both wild-type and CGRP-sensitized transgenic (nestin/hRAMP1)
mice … observations of diarrhea were made during light aversion experiments with α-CGRP. …

… -mAb fremanezumab (TEV-48125) modulates meningeal sensory pathways. To answer this
… Triptans and other 5HT1D agonists also block the increase in CGRP gene promoter activity …

… Modulation of CGRP-induced light 413 aversion in wild-type mice by a 5-HT(1B/D) agonist.
J Neurosci 2012; 32: 15439-15449. 414 DOI: 10.1523/JNEUROSCI.3265-12.2012. 415 17. …

… We have shown that in wild-type C57BL/6J mice, injection of CGRP … antagonist can reverse
these CGRP-induced changes (31… that are efficacious in mouse light-aversion studies (51…

… Second, wild-type mice were more photophobic than controls … CGRP-induced changes also
play a role in other neurologic … to consider treatments that modulate peripheral and central …

… and displayed light aversive behavior… wild-type mice. Additional research showed that
administering a CGRP antagonist or rizatriptan blocked CGRP-induced photophobia in these mice…

… towards both human and mouse receptors, and can alleviate CGRP-induced behaviors in
… ., Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT (1B/D) agonist. J …