[HTML][HTML] Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases
U Billmeier, W Dieterich, MF Neurath… - World journal of …, 2016 - ncbi.nlm.nih.gov
… colitis, Transmembrane tumor necrosis factor, Apoptosis … inflammatory bowel diseases to
anti-tumor necrosis factor (TNF) therapy, it is mandatory to understand the pleiotropic effects of …
anti-tumor necrosis factor (TNF) therapy, it is mandatory to understand the pleiotropic effects of …
New insights into the mechanisms of action of anti–tumor necrosis factor-α monoclonal antibodies in inflammatory bowel disease
… Many of those actions are mediated by the binding of the antibodies to … molecular factors
and cells. In this review, we have highlighted new information on the mechanism of actions of …
and cells. In this review, we have highlighted new information on the mechanism of actions of …
Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases
CM Olesen, M Coskun, L Peyrin-Biroulet… - Pharmacology & …, 2016 - Elsevier
… pro-inflammatory cytokines, chemokines, adhesion molecules, … Infliximab is a chimeric
antibody, in which a part of the Fab … Adalimumab and golimumab are fully human IgG1 antibodies. …
antibody, in which a part of the Fab … Adalimumab and golimumab are fully human IgG1 antibodies. …
Mechanisms of action of anti–tumor necrosis factor α agents in Crohn's disease
STC Peake, D Bernardo, ER Mann… - Inflammatory Bowel …, 2013 - academic.oup.com
… anti–tumor necrosis factor α (TNF-α) therapies. The TNF-α cytokine is a major mediator in the
pathophysiology of inflammation … molecule has two antigen-binding sites, a single antibody …
pathophysiology of inflammation … molecule has two antigen-binding sites, a single antibody …
Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease
BL Cohen, DB Sachar - Bmj, 2017 - bmj.com
… of being monoclonal antibodies are small molecules and thus relatively non-immunogenic. …
a small molecule fusion protein that is not immunogenic, unlike monoclonal antibodies. Early …
a small molecule fusion protein that is not immunogenic, unlike monoclonal antibodies. Early …
[PDF][PDF] Update on the mechanisms of action of anti-TNF-α antibodies and their clinical implications in inflammatory bowel disease
P Eder, K Linke, J Witowski - Pol Arch Med Wewn, 2016 - researchgate.net
… mechanisms of action of antitumor necrosis factor α (anti-TNF-α) antibodies in the therapy
of inflammatory bowel … can react with three IFX molecules and one molecule of either IFX or …
of inflammatory bowel … can react with three IFX molecules and one molecule of either IFX or …
Tumor necrosis factor blockade for treatment of inflammatory bowel disease: efficacy and safety
B Ngo, CP Farrell, M Barr, K Wolov… - Current Molecular …, 2010 - ingentaconnect.com
… Tumor Necrosis Factor (TNF), a key, early signaling molecule in the inflammatory cascade.
… These antibodies are able to bind both soluble and membrane-bound TNF and block its …
… These antibodies are able to bind both soluble and membrane-bound TNF and block its …
Novel pharmacological therapy in inflammatory bowel diseases: beyond anti-tumor necrosis factor
… Biologics are generally large molecules (eg, monoclonal antibodies) that require parenteral
… -generation molecule that specifically interferes with leukocyte homing into the inflamed gut …
… -generation molecule that specifically interferes with leukocyte homing into the inflamed gut …
Optimizing anti-tumor necrosis factor strategies in inflammatory bowel disease
WJ Sandborn - Current gastroenterology reports, 2003 - Springer
… with the anti–tumor necrosis factor (TNF) antibody infliximab … use of anti-TNF therapy for
inflammatory bowel disease. … is linked to the ability of the molecule to induce T-cell apoptosis. …
inflammatory bowel disease. … is linked to the ability of the molecule to induce T-cell apoptosis. …
Anti-TNF antibodies in inflammatory bowel disease: do we finally know how it works?
A Oikonomopoulos, WK van Deen… - Current drug …, 2013 - ingentaconnect.com
… However, the cellular and molecular mechanisms of actions of the anti-TNF antibodies …
anti–tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor …
anti–tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor …