… In addition, we also comprehensively investigated the clinical outcomes of off-label DOACs
administration in AF patients with different baseline characteristics in multiple subgroups. …

… It is, therefore, not surprising that physicians would favor under-dosing for older Asian patients
with some renal dysfunction in order to lower the risk of a major bleeding event. The RELY …

… the clinical outcomes of AF patients treated with on-label or off-label dosing NOACs. We …
between inappropriate dosing of 4 NOACs and clinical outcomes of an Asian AF population in …

… is associated with clinical outcomes, … off-label underdose regimens and better renal
function were important factors. Physicians should avoid pre-emptive dose reduction in patients …

… dosing across four NOACs and the associations between off‐label NOAC dosing and clinical
outcomes in patients with … dosing across all 4 NOACs and their clinical effects in Asian AF …

Aims Worldwide observational studies are evidencing discordance between guidelines and
real‐world practice regarding direct oral anticoagulant drug (DOAC) doses. This systematic …

… clinical outcome and all-cause death comparing off-label underdosing vs on-label dosing
of direct oral anticoagulants… As expected, off-label underdosing was most common in Asian …

… and the possible clinical outcomes of DOAC off-label doses in the … off-label doses of DOACs
would be appropriate or not for AF … the off-label prevalence in other regions except for Asia, …

… registry of non-valvular atrial fibrillation (AF) patients with DOAC: the DIRECT registry (n=
2,216… We analyzed patients taking standard dose (n= 907) and off-label reduced dose (n= 338) …

… Direct oral anticoagulants (DOACs) are currently the first-line … In addition, warfarin was
used as the comparator; thus, we cannot estimate the HRs for clinical outcomes of off-label …