Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
JD Freedman, J Hagel, EM Scott, I Psallidas… - EMBO molecular …, 2017 - embopress.org
… Finally, we assessed the ability of BiTEs to activate T‐cell cytotoxicity to SKOV3 target cells
in the presence of immunosuppressive ascites or pleural fluid following infection with EnAd‐…
in the presence of immunosuppressive ascites or pleural fluid following infection with EnAd‐…
Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
J de Sostoa, CA Fajardo, R Moreno, MD Ramos… - … of cancer, 2019 - Springer
… along with the T cell-mediated cytotoxicity of CAFs were … target cancer cells through
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
JPW Heidbuechel, CE Engeland - Journal of hematology & oncology, 2021 - Springer
… On-target off-tumor toxicity as a safety concern of redirecting … slices derived from prostate
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
Arming oncolytic adenoviruses with bi-specific T-cell engagers to improve antitumor efficacy
CA Fajardo Calderón - 2017 - diposit.ub.edu
… a new class of antibodies that re-direct T-cells to cancer cells, … that another oncolytic adenovirus
expressing a chimeric BiTE … T-cell activation, proliferation, and cell-mediated cytotoxicity …
expressing a chimeric BiTE … T-cell activation, proliferation, and cell-mediated cytotoxicity …
[HTML][HTML] Bispecific T cell engagers and their synergistic tumor immunotherapy with oncolytic viruses
Q Huang, WQ Cai, ZW Han, MY Wang… - … Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
… less cytotoxic to non-cancer cells but increase their ability to … The replication of oncolytic
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
An oncolytic virus expressing a T-cell engager simultaneously targets cancer and immunosuppressive stromal cells
JD Freedman, MR Duffy, J Lei-Rossmann, A Muntzer… - Cancer research, 2018 - AACR
… oncolytic adenovirus that encodes a bispecific antibody … A, Cytotoxicity in T-cell and NHDF
cocultures was assessed … tumor biopsies with EnAd-FAP-BiTE led to tumor-associated T-cell …
cocultures was assessed … tumor biopsies with EnAd-FAP-BiTE led to tumor-associated T-cell …
Arming oncolytic viruses with bispecific T cell engagers (BiTEs) for expression and secretion into the tumour microenvironment
J Freedman - 2017 - ora.ox.ac.uk
… engager (BiTE) binds to a selected antigen on target cells and … This strategy can potentiate
the cytotoxicity of EnAd and we … using BiTEexpressing oncolytic adenoviruses (chapter five). 4…
the cytotoxicity of EnAd and we … using BiTEexpressing oncolytic adenoviruses (chapter five). 4…
Bi-and tri-specific T cell engager-armed oncolytic viruses: next-generation cancer immunotherapy
… supported bystander cell-mediated cytotoxicity. In two distinct … Indeed, treatment of fresh
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
Oncolytic adenovirus in cancer immunotherapy
M Peter, F Kühnel - Cancers, 2020 - mdpi.com
… The goal of this review is to provide an introduction into the … T cells to cancer cells are
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …
Oncolytic adenoviruses for cancer therapy
… to induce oncolytic effects and a tumor-specific cytotoxic T-… target antigens triggers T-cell
activation leading to target cell … microenvironment of liquid cancer biopsies (malignant …
activation leading to target cell … microenvironment of liquid cancer biopsies (malignant …