[HTML][HTML] Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism

D Richani, CF Lavea, R Kanakkaparambil… - Scientific Reports, 2019 - nature.com
… mouse oocytes can use the cAMP degradation product AMP to generate ATP via the adenosine
salvage pathway… elevation of cAMP in IVM cumulus-oocyte complexes alters ATP levels. …

Nutrient pathways regulating the nuclear maturation of mammalian oocytes

SM Downs - Reproduction, Fertility and Development, 2015 - CSIRO Publishing
energy to fuel the myriad metabolic pathways that participate … different aspects of energy
metabolism and how they interact … support nucleotide formation via HX salvage but not de novo …

The participation of energy substrates in the control of meiotic maturation in murine oocytes

SM Downs, AM Mastropolo - Developmental biology, 1994 - Elsevier
… was the sole energy source, dibutyryl cyclic AMP (dbcAMP) … that are known to modulate
CAMP levels: hypoxanthine, … hormone on cyclic adenosine monophosphate level and on …

High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle

X Wen, D Perrett, N Jones, AJ Tozer, SM Docherty… - Metabolism, 2010 - Elsevier
… of cyclic adenosine monophosphate (AMP) metabolism and … inhibits oocyte meiotic arrest
by inhibiting oocyte cyclic AMProle in ATP salvage pathways and its established metabolism, …

Involvement of purine nucleotide synthetic pathways in gonadotropin‐induced meiotic maturation in mouse cumulus cell‐enclosed oocytes

SM Downs - Molecular Reproduction and Development …, 1997 - Wiley Online Library
… tyryl cyclic AMP (dbcAMP) (to maintain meiotic arrest), plus … maturation appears to be brought
about by modulation of the … de novo pathway after phosphorylation by adenosine kinase …

Metabolic control of oocyte development

S Zhu, Q Wang - Biology of Reproduction, 2022 - academic.oup.com
involvement in epigenetic establishment during oocyte … ) cycle to produce adenosine
triphosphate (ATP) and metabolic … Moreover, L-carnitine also modulates glucose metabolism and …

Transcriptomic analysis of cyclic AMP response in bovine cumulus cells

DR Khan, C Guillemette, MA Sirard… - Physiological …, 2015 - journals.physiology.org
… transfer cyclic adenosine 3′5′-monophosphate (cAMP) to the oocyte where one role of …
The downstream pathways through which cAMP modulates meiotic maturation are not fully …

Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence

D Richani, KR Dunning, JG Thompson… - Human reproduction …, 2021 - academic.oup.com
… the adenosine salvage pathway, a two-step enzymatic process that phosphorylates AMP to
Cyclic AMP and cGMP modulation has led to significant improvements in embryo yield in …

Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence

D Richani, RB Gilchrist - Biology of Reproduction, 2022 - academic.oup.com
Cyclic AMP and cGMP levels decline following oocyte … I stage, it plays a dual role in meiotic
regulation since it also mediates … Cyclic AMP or cGMP modulation using pre-IVM has shown …

Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells

N Akin, L von Mengden, AC Herta… - Biology of …, 2021 - academic.oup.com
… downstream elements is suggesting its possible involvement … is regulated through
phosphorylation by cyclic AMP (cAMP)-… it is possible that CNP is modulating the PKA-dependent …