… distribution of adenovector through the ear. In this study we demonstrate that delivery of
adenovector to … delivery. Ad5 vector transduction and expression of the gfp transgene occurred …

… to tissues. The interplay between diffusion and clearance is key to determining the distribution
in the inner ear of substances applied to the RWM. Substances cleared from the fluids at …

… transfer to the inner ear is the means and route of delivery. Vector … Adenovirus vector containing
the GDNF gene (Ad-GDNF) … through an intact round window membrane in mouse. Hum …

… delivered a novel adenovirus vector that targets delivery of genes to … After vector delivery to
one inner ear in this bilateral … The opening was sealed with a piece of tissue and the wound …

… Here, we use adenoviral delivery of dominant-negative KCNQ4 to confirm … their contribution
to sensory signaling in the inner ear. … Because the tissue we harvested for these experiments …

… Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse.
Hear Res., 2007, 227, 53-58. [113] Oestreicher, E.; Arnold, W.; Ehrenberger, K.; Felix, D. …

… inner ear and whether a cocktail of GDNF and TGF-β1 transgenes provides enhanced protection
of the inner ear … demonstrate the expression of the TGF-β receptors in cochlear tissues. …

… Table I shows the expression of GFP within the ear tissues. After delivery by all three viral …
of GFP, which was widely distributed in many types of cells in the inner ear, especially in the …

… Most use is empiric and no good pharmacology studies have … adenovector, Kawamoto
demonstrated the delivery of math1 … Delivery of a viral vector into the mouse inner ear. Injection of …

… , and well-studied pharmacodynamics, adenovirus is … Ad28 adenovector used in these studies
expresses the mouse … and evaluated at 1 month following vector delivery to the inner ear. …