… In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …

… PI3K-Akt pathway regulates many enzymes implicated in … ) and modulation of neuronal
survival pathway. Akt inhibits cell … that in AD central PI3K-Akt signaling is impaired and those …

… Having said that, one report exists of Akt protecting a neuronal cell line from … is also involved
in many other signalling pathways, including the β-catenin-TCF/LEF transcriptional pathway, …

… Given that PIKE-S is a downstream mediator of another neurotrophin, NGF (Ye et al.,
2000, 2002), we hypothesized that PIKE might be involved in the BDNF signaling. To test this …

… While a role for PI3K signaling in the regulation of neuronal survival is well established,
our findings implicating the ERK1/2 pathway in motoneuron survival contributes to a …

… in promoting cell survival but more recently has been shown … and identify intracellular
signalling molecules implicated in … of FKHR acts to prevent neuronal apoptosis. A growing body …

… neurons in primary culture with the shRNA Akt only resulted in a low degree of loss of neuronal
survival … To ascertain whether PN was involved in glutamate-mediated neuroprotection, …

… neurons from oxidative stress-induced apoptosis and that the PI3K/Akt signal pathway is
involved in … However, the role of insulin as a survival factor in the protection of retinal neurons is …

… neurons [27]. Results have suggested that the neuroprotective action of BDNF is involved in
PI3K/Akt signaling pathway … study, BDNF promoted significant neuronal survival and growth, …

… signaling pathway. An intestinal-secreted neurotrophic factor, glucagon-like peptide-1 (GLP-1),
for example, this molecule is implicated in neuronal survival … DNA damage to neurons. …