Prednisolone pharmacokinetics and pharmacodynamics in relation to sex and race

MH Magee, RA Blum, CD Lates… - The Journal of Clinical …, 2001 - Wiley Online Library
sex (by 125% in men and 208% in women, p < 0.01). The IC50 or SC50 values for effects of
prednisolone … are some prednisolone PK/PD differences related to sex and race. However, …

Gender‐based effects on methylprednisolone pharmacokinetics and pharmacodynamics

KH Lew, EA Ludwig, MA Milad… - Clinical …, 1993 - Wiley Online Library
… developed pharmacodynamic models. These models relate the changing methylprednisolone
Influence of sex and oral contraceptive steroids on paracetamol metabolism. Br J Clin …

Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation

TK Bergmann, KA Barraclough, KJ Lee… - … pharmacokinetics, 2012 - Springer
… reports of a relationship between prednisolone pharmacokinetics and … Dosing of prednisolone
and prednisone in transplantation is … recipients, the patient’s sex was identified as the only …

Sex differences in pharmacokinetics and pharmacodynamics

M Gandhi, F Aweeka, RM Greenblatt… - Annu. Rev. Pharmacol …, 2004 - annualreviews.org
… basis for sex-related disparities in pharmacokinetics and … -1 gene have been shown to group
by race (28, 29), gender-… significant differences in prednisolone pharmacokinetics by state …

Gender differences in human pharmacokinetics and pharmacodynamics

CV Fletcher, EP Acosta, JM Strykowski - Journal of adolescent health, 1994 - Elsevier
… promises our ability to detect sex-related differences in pharmacokinetics, drug efficacy and
… strongly indicate racial and gender differences exist in drug metabolism. Corticosteroids are …

Pharmacokinetic/pharmacodynamic model for prednisolone inhibition of whole blood lymphocyte proliferation

MH Magee, RA Blum, CD Lates… - British journal of clinical …, 2002 - Wiley Online Library
prednisone, T lymphocyte cell counts decreased in relation … by the active metabolite,
prednisolone. This results in … pharmacokinetics of prednisolone in relation to sex and race. …

Racial differences in the pharmacokinetics of methylprednisolone in black and white renal transplant recipients

KM Tornatore, KA Reed… - … : The Journal of Human …, 1993 - Wiley Online Library
… with stable renal function, sexand (approximate) age-… of these agents in African blacks
compared with whites.i0-i2 … a previous report of methylprednisolone disposition in renal transplant …

Sex differences in pharmacokinetics and pharmacodynamics

OP Soldin, DR Mattison - Clinical pharmacokinetics, 2009 - Springer
… , it is plausible that sex-related disparities in pharmacokinetics arise from variations in the …
studies compared the pharmacokinetics of midazolam, erythomycin and prednisolone

[PDF][PDF] Do sex and ethnicity influence drug pharmacokinetics in solid organ transplantation?

AS Mathis, GS Friedman… - GRAFT …, 2002 - triggered.edina.clockss.org
… the suppressive pharmacodynamic effects of prednisolone.The pharmacokinetics of sirolimus
… on factors underlying pharmacokinetic variability as they probably relate to importance in …

Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I

M Anthony, MJ Berg - Journal of women's health & gender-based …, 2002 - liebertpub.com
… shop reveal some important biological sex and ethic/racial differences in pharmacology. It …
of steroids. In rodent systems, expression of a multidrug transporter is related to biological sex. …