… total synthesis, namely the design and synthesis of molecular probes—analogues of the
natural products… of the natural product and ultimately broader questions in biology or medicine. …

… It was by way of total synthesis that the issues concerning the … a platform for a first round of
diverted total synthesis. (55) Yet, it … also functionally relevant was probed in the following ways: …

… as alternative therapeutic agents and biological probes. … target can inspire and guide structure
editing. These data are not … The underlying theory behind natural product total synthesis …

… well as the biological activity of the resulting compounds. A previous “diverted total synthesis”
… In order to probe this possible role, it was planned to replace the α,β-unsaturated ester of 1 …

… editing techniques that enable the assembly of these … is important because if this diversion
is constitutive it slows … and genetic control to probe natural product pathways in new and …

… “diverted total synthesis”, “chemical or molecular editing”, 5 and “function-oriented synthesis…
the limitations of parent natural product structures, such as lack of accessibility or viable …

… prepare these molecules, including diverted total synthesis (… to lead compounds and natural
product-based probes. Herein, … natural products and the impacts of this approach on organic …

… molecular mechanics minimization with the Merck molecular … In a mechanism diverting from
the classical assembly line … III spectrometer equipped with a cold probe at 500 MHz and 600 …

… probes for biological targets or as modulators of disease states. It seems logical for one to
think of the shape of a molecule … These include molecular editing [25], libraries from libraries […

… 50:50 mixture of products at the C3 and C7 positions in 56% total yield (Fig. 3b). This … -selective
modifications in chiral polyol-containing natural products 24,25 , we wondered if a …