… tumor microenvironment, which poses the importance of these proteases beyond the central
function as matrix scissors… proteases of cancer. This article is part of a Special Issue entitled: …

… function in ECM and pro-collagen processing, organogenesis, homeostasis and angiogenesis
[17]. … proteases play also a role in the regulation of growth and angiogenesis factors. For …

… type I collagen may not be a relevant MMP substrate in glioma, this … roles of MMPs in each
of these angiogenic processes. … and antiangiogenic roles in tumor angiogenesis Citation106–…

… primary glioma cell tumor formation, invasion, angiogenesis, and … to play important role in
collagens maturation and function. Inhibition … of HSP47 induced tumor progression of GBM, we …

… therapeutic strategy in suppressing angiogenesis and tumor progression, especially if these
… These examples highlight the importance of studying tumor angiogenesis and testing the …

… and polarization, tumor angiogenesis, and tumor fibrosis … matrix degradation and absorption.
After macrophage depletion, the proportion of Sirius red-staining positive collagen matrix in …

… Collagens play a vital role in maintaining tissue architecture and in forming a stable … cancer
cells with blood supply. Due to its importance in tumor progression, tumor angiogenesis is a …

… roles in the collagen hierarchy, was reported to promote progression and chemoresistance
and affect tumor-… ) and enhance glioma angiogenesis through HIF1α-VEGFR2 signaling (35). …

… and 13 and degrade collagens and laminin [99]. An interesting aspect of the MT-MMPs is their
… (2001) The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. …

… more innovation in the coming years with advancement in patient prognosis and outcome. …
directly physiologic role. Using aortic ring assays as a proxy for tumor angiogenesis, current …