Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN

R Ji, F Jia, X Chen, Z Wang, W Jin, J Yang - Archives of Biochemistry and …, 2022 - Elsevier
… The present study aimed to explore whether salidroside can incur a protective effect on …
suggest that salidroside effectively can alleviate oxidative stress in DHT-induced KGN cells. …

Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model

L Chen, Q Mo, Y Wu, W Chen, K Deng… - Free Radical …, 2024 - Taylor & Francis
… ovary by inducing follicular cell apoptosis through oxidative stress. The increase of … of
salidroside in POF are scarce. We asked whether Salidroside alleviates oxidative stress and …

[HTML][HTML] Pharmacological effects of salidroside on central nervous system diseases

M Jin, C Wang, Y Xu, Z Zhang, X Wu, R Ye… - Biomedicine & …, 2022 - Elsevier
… SAL on inflammation, oxidative stress, apoptosis, autophagy, … suppress neuron apoptosis
and alleviate neuron damage. The … induce cell apoptosis through several signaling pathways (…

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

YP Jiang, BG Liu, Y Dang, LJ Liu, Y Pang… - Frontiers in …, 2024 - frontiersin.org
… SAL alleviates oxidative stress in vivo and in vitro: (A) effects of SAL … apoptotic signaling
pathway, and cellular response to hypoxia. Through analysis, it was found that oxidative stress

… protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in …

Y Yao, H Wang, Y Yang, Z Jiang, H Ma - Molecular immunology, 2023 - Elsevier
… found that DHEA relieves oxidative stress and inflammation … AMPK-Nrf2 signaling pathway
to increase antioxidant capacity and protect against mitochondrial dysfunction, which reduces

Lycopene mitigates DHT-induced apoptosis and oxidative stress in human granulosa cell line KGN by regulating the Nrf2 pathway

Y Chen, M Zhao, X Li, Y Liu, Y Shang - Molecular & Cellular Toxicology, 2024 - Springer
… In summary, this work revealed that lycopene alleviates oxidative stress and apoptosis in
KGN cells in the presence of DHT, which at least partly by depending on the activation of Nrf2 …

[HTML][HTML] Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured …

S Yang, Z Xie, T Pei, Y Zeng, Q Xiong, H Wei, Y Wang… - Chinese Medicine, 2022 - Springer
… that salidroside can reduce oxidative stress and apoptosis of … epileptic rats by activating Nrf2
are signaling pathway [28], and … investigated whether salidroside could alleviate ferroptosis …

[HTML][HTML] The Antioxidant Salidroside Ameliorates the Quality of Postovulatory Aged Oocyte and Embryo Development in Mice

K Liu, L Zhang, X Xu, L Xiao, J Wen, H Zhang, S Zhao… - Antioxidants, 2024 - mdpi.com
… , SAL alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced
In this study, we provided that SAL moderated oxidative stress, alleviated mitochondrial …

[HTML][HTML] Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review

S Liu, Y Jia, S Meng, Y Luo, Q Yang, Z Pan - International Journal of …, 2023 - mdpi.com
… 4 (NOX4) expression reduces OS and apoptosis in rat GCs … salidroside can alleviate
dihydrotestosterone-induced OS in KGN cell lines by activating the AMPK/Nrf2/HO-1/NQO1 pathway

[HTML][HTML] Salidroside supplementation affects in vitro maturation and preimplantation embryonic development by promoting meiotic resumption

S Shi, Z Geng, X Yu, B Hu, L Liu, Z Chi, L Qu, M Zhang… - Genes, 2023 - mdpi.com
… is often delayed due to oxidative stress and mitochondrial function, resulting … Using a variety
of experimental methods, the efficiency of salidroside in protecting mature oocytes, apoptosis